Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 560-565.doi: 10.7518/gjkq.2018.05.011

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Regulation of programmed death receptor-1 and its ligand signalling pathway and its progress in the treatment of head and neck squamous cell carcinoma

Lu Mao1,2,Houyu Ju1,Guoxin Ren1()   

  1. 1. Dept. of Oral and Maxillofacial Head and Neck Tumor, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai 200011, China
    2. Weifang Medical University, Weifang 261053, China
  • Received:2017-12-31 Revised:2018-05-14 Online:2018-09-01 Published:2018-09-20
  • Contact: Guoxin Ren E-mail:renguoxincn@sina.com

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Abstract:

Tumours are closely related to the immune system, and they can escape immune surveillance by stimulating immune inhibitory receptors, which can be blocked by the inhibitory receptors on the T cell. A potential strategy for anti-tumour immune therapy can be developed based on the abovementioned fact. Programmed death receptor-1 (PD-1)/programmed death-ligand 1 (PD-L1) is a newly identified negative co-stimulatory pathway that promotes immune escape. This review discusses the biological characteristics and functions of PD-1/PD-L1, as well as the application of PD-1/PD-L1 antibody in tumour therapy.

Key words: head and neck squamous carcinoma, programmed death receptor, programmed death ligand, immune checkpoint, immune escape

CLC Number: 

  • R730.3

TrendMD: 
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