Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (1): 25-31.doi: 10.7518/gjkq.2023013

• Periodontitis • Previous Articles     Next Articles

Research progress on resveratrol for the treatment of periodontitis and its bioavailability

Li Qiong1(),Yu Weixian1,2()   

  1. 1.Dept. of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2022-05-25 Revised:2022-09-21 Online:2023-01-01 Published:2023-01-09
  • Contact: Weixian Yu E-mail:1520972910@qq.com;ywx@jlu.edu.cn
  • Supported by:
    Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2021-893-22)

RichHTML

28

PDF (PC)

917

Abstract:

Resveratrol is a natural polyphenol compound that has extensive pharmacological activities and can be found in plants, such as dark grapes, berries, and peanut skins. Experimental studies showed that it plays a therapeutic role in periodontitis, such as anti-inflammation, anti-oxidation, anti-bacteria, inhibition of bone resorption, and promotion of bone formation. However, resveratrol also faces some problems, such as rapid absorption, low bioavailability, and low water solubility. The improvement of cosolvent and the use of nanoparticles can solve these problems. This article reviews the research progress on resveratrol for the treatment of periodontitis and its bioavailability to provide reference for further research on resveratrol as a therapeutic drug and the development of suitable drug dosage forms.

Key words: resveratrol, periodontitis, bioavailability

CLC Number: 

  • R 781.4

TrendMD: 

Fig 1

Structural formula of trans-resveratrol (top) and cis-resveratrol (bottom)"

1 Zheng SW, Yu SW, Fan XM, et al. Porphyromonas gingivalis survival skills: immune evasion[J]. J Periodontal Res, 2021, 56(6): 1007-1018.
2 Richards D. Review finds that severe periodontitis affects 11% of the world population[J]. Evid Based Dent, 2014, 15(3): 70-71.
3 Oh WY, Shahidi F. Antioxidant activity of resveratrol ester derivatives in food and biological model systems[J]. Food Chem, 2018, 261: 267-273.
4 Berta GN, Romano F, Vallone R, et al. An innovative strategy for oral biofilm control in early childhood based on a resveratrol-cyclodextrin nanotechnology approach[J]. Materials (Basel), 2021, 14(14): 3801.
5 Jarosova V, Vesely O, Doskocil I, et al. Metabolism of cis- and trans-resveratrol and dihydroresveratrol in an intestinal epithelial model[J]. Nutrients, 2020, 12(3): E595.
6 Trela BC, Waterhouse AL. Resveratrol: isomeric molar absorptivities and stability[J]. J Agric Food Chem, 1996, 44(5): 1253-1257.
7 叶庆元, 李子涵, 王垭铮, 等. 间充质干细胞来源凋亡囊泡缓解牙龈卟啉单胞菌脂多糖诱导下巨噬细胞促炎状态的研究[J]. 中华口腔医学杂志, 2021, 56(8): 791-798.
Ye QY, Li ZH, Wang YZ, et al. Study on the effect of apoptosis vesicle derived from mesenchymal stem cells on the pro-inflammatory state of macrophages induced by lipopolysaccharide of Porphyromonas gingivalis [J]. Chin J Stomatol, 2021, 56(8): 791-798.
8 Ying SQ, Tan MM, Feng G, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress[J]. Theranostics, 2020, 10(21): 9789-9807.
9 Zare Javid A, Hormoznejad R, Yousefimanesh HA, et al. The impact of resveratrol supplementation on blood glucose, insulin, insulin resistance, triglyceride, and periodontal markers in type 2 diabetic patients with chronic periodontitis[J]. Phytother Res, 2017, 31(1): 108-114.
10 Li LH, Li JX, Wang YJ, et al. Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/β‑catenin signaling pathways[J]. Genet Mol Biol, 2021, 44(3): e20200349.
11 Corrêa MG, Pires PR, Ribeiro FV, et al. Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats[J]. PLoS One, 2018, 13(10): e0204414.
12 Cirano FR, Molez AM, Ribeiro FV, et al. Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats[J]. J Periodontol, 2021, 92(5): 748-759.
13 Javid AZ, Hormoznejad R, Yousefimanesh HA, et al. Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis[J]. Diabetes Metab Syndr, 2019, 13(4): 2769-2774.
14 Yuan JK, Wang XX, Ma D, et al. Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway[J]. Mol Med Rep, 2020, 21(5): 2085-2094.
15 Bahar B, Singhrao SK. An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model[J]. Mol Biol Rep, 2021, 48(1): 147-156.
16 Corrêa MG, Absy S, Tenenbaum H, et al. Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation[J]. J Periodontal Res, 2019, 54(3): 225-232.
17 Kugaji MS, Kumbar VM, Peram MR, et al. Effect of resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease[J]. APMIS, 2019, 127(4): 187-195.
18 Ben Lagha A, Andrian E, Grenier D. Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis [J]. Mol Oral Microbiol, 2019, 34(3): 118-130.
19 Pothapur KK, Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu India. Identification of protein targets in red complex organisms binding with resveratrol[J]. Bioinformation, 2020, 16(11): 837-842.
20 Abdullahi M, Olotu FA, Soliman ME. Solving the riddle: unraveling the mechanisms of blocking the binding of leukotoxin by therapeutic antagonists in periodontal diseases[J]. J Cell Biochem, 2018, 119(11): 9364-9379.
21 Casati MZ, Algayer C, Cardoso da Cruz G, et al. Resveratrol decreases periodontal breakdown and modulates local levels of cytokines during periodontitis in rats[J]. J Periodontol, 2013, 84(10): e58-e64.
22 Wang YJ, Zhao P, Sui BD, et al. Resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates[J]. Exp Mol Med, 2018, 50(6): 1-15.
23 Li W, Huang X, Yu W, et al. Activation of functional somatic stem cells promotes endogenous tissue regeneration[J]. J Dent Res, 2022, 101(7): 802-811.
24 Adhikari N, Prasad Aryal Y, Jung JK, et al. Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model[J]. J Periodontal Res, 2021, 56(4): 735-745.
25 Lançon A, Delmas D, Osman H, et al. Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process[J]. Biochem Biophys Res Commun, 2004, 316(4): 1132-1137.
26 Gowd V, Karim N, Shishir MRI, et al. Dietary polyphenols to combat the metabolic diseases via altering gut microbiota[J]. Trends Food Sci Technol, 2019, 93: 81-93.
27 Walle T, Hsieh F, DeLegge MH, et al. High absorption but very low bioavailability of oral resveratrol in humans[J]. Drug Metab Dispos, 2004, 32(12): 1377-1382.
28 Wang XC, Parvathaneni V, Shukla SK, et al. Inhalable resveratrol-cyclodextrin complex loaded biodegradable nanoparticles for enhanced efficacy against non-small cell lung cancer[J]. Int J Biol Macromol, 2020, 164: 638-650.
29 Zupančič Š, Lavrič Z, Kristl J. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature[J]. Eur J Pharm Biopharm, 2015, 93: 196-204.
30 Verheijen M, Lienhard M, Schrooders Y, et al. DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro [J]. Sci Rep, 2019, 9(1): 4641.
31 Loftsson T, Brewster ME. Pharmaceutical applicat-ions of cyclodextrins: basic science and product development[J]. J Pharm Pharmacol, 2010, 62(11): 1607-1621.
32 Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future[J]. Nat Rev Drug Discov, 2004, 3(12): 1023-1035.
33 Savić-Gajić I, Savić I, Nikolić V, et al. The improvement of photostability and antioxidant activity of trans-resveratrol by cyclodextrins[J]. Adv Techol, 2017, 6(2): 18-25.
34 Yang ZQ, Argenziano M, Salamone P, et al. Preclinical pharmacokinetics comparison between resveratrol 2-hydroxypropyl‑β‑cyclodextrin complex and re-sveratrol suspension after oral administration[J]. J Inclusion Phenom Macrocycl Chem, 2016, 86(3/4): 263-271.
35 Lim YRI, Preshaw PM, Lim LP, et al. Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects[J]. Sci Rep, 2020, 10(1): 9072.
36 Javanbakht S, Shaabani A. Carboxymethyl cellulose-based oral delivery systems[J]. Int J Biol Macromol, 2019, 133: 21-29.
37 Li X, Liu XC, Ding X, et al. Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats[J]. Oral Dis, 2022. doi: 10.1111/odi.14148 .
doi: 10.1111/odi.14148
38 Li J, Song S, Meng JS, et al. 2D MOF periodontitis photodynamic ion therapy[J]. J Am Chem Soc, 2021, 143(37): 15427-15439.
39 Chimento A, de Amicis F, Sirianni R, et al. Progress to improve oral bioavailability and beneficial effects of resveratrol[J]. Int J Mol Sci, 2019, 20(6): E1381.
40 Shi JY, Zhang Y, Zhang XM, et al. Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy[J]. J Nanobiotechnology, 2021, 19(1): 429.
41 Kianfar E. Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles[J]. J Nanobiotechnology, 2021, 19(1): 159.
42 Koh LD, Cheng Y, Teng CP, et al. Structures, mechanical properties and applications of silk fibroin materials[J]. Prog Polym Sci, 2015, 46: 86-110.
43 Lozano-Pérez AA, Rivero HC, Pérez Hernández MDC, et al. Silk fibroin nanoparticles: efficient vehicles for the natural antioxidant quercetin[J]. Int J Pharm, 2017, 518(1/2): 11-19.
44 Giménez-Siurana A, Gómez García F, Pagan Bernabeu A, et al. Chemoprevention of experimental periodontitis in diabetic rats with silk fibroin nanoparticles loaded with resveratrol[J]. Antioxidants (Basel), 2020, 9(1): E85.
45 Guo LX, Zhao HY, Zheng X. The clinical effects of resveratrol on atherosclerosis treatment and its effect on the expression of NADPH oxidase complex genes in vascular smooth muscle cell line[J]. Cell Mol Biol (Noisy-le-grand), 2021, 67(3): 148-152.
46 Abozaid OAR, Sallam MW, El-Sonbaty S, et al. Resveratrol-selenium nanoparticles alleviate neuroinflammation and neurotoxicity in a rat model of Alzheimer’s disease by regulating Sirt1/miRNA-134/GSK3β expression[J]. Biol Trace Elem Res, 2022, 200(12): 5104-5114.
[1] Fu Yu, He Wei, Huang Lan. Ferroptosis and its implication in oral diseases [J]. Int J Stomatol, 2024, 51(1): 36-44.
[2] Luo Xiaojie,Wang Dexu,Chen Xiaotao. Relationship between periodontitis and ferroptosis based on bioinformatics analysis [J]. Int J Stomatol, 2023, 50(6): 661-668.
[3] Huang Yuanhong,Peng Xian,Zhou Xuedong.. Progress in research into the effect of Rhizoma Drynariae on the treatment of bone-related diseases in the oral cavity [J]. Int J Stomatol, 2023, 50(6): 679-685.
[4] Hu Jia,Wang Xiuqing,Lu Guoying,Huang Xiaojing.. Regenerative endodontic procedures for permanent tooth with immature apices in adult patients [J]. Int J Stomatol, 2023, 50(6): 686-695.
[5] Gong Meiling,Cheng Xingqun,Wu Hongkun.. Research progress on the correlation between Parkinson’s disease and periodontitis [J]. Int J Stomatol, 2023, 50(5): 587-593.
[6] Xu Zhibo,Meng Xiuping.. Research progress on mechanism of Enterococcus faecalis escaping host immune defense [J]. Int J Stomatol, 2023, 50(5): 613-617.
[7] Sun Jia,Han Ye,Hou Jianxia. Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia [J]. Int J Stomatol, 2023, 50(3): 329-334.
[8] Liang Zhiying,Zhao Yuanxi,Zhu Jiani,Su Qin.. Retrospective analysis of clinical data of 288 cases of endodontic microsurgery on anterior teeth [J]. Int J Stomatol, 2023, 50(2): 166-171.
[9] Liu Tiqian,Liang Xing,Liu Weiqing,Li Xiaohong,Zhu Rui.. Research progress on the role and mechanism of occlusal trauma in the development of periodontitis [J]. Int J Stomatol, 2023, 50(1): 19-24.
[10] Huang Weikun,Xu Qiuyan,Zhou Ting.. Role of baicalin and mechanisms through which baicalin attenuates oxidative stress injury induced by lipopolysaccharide on macrophages [J]. Int J Stomatol, 2022, 49(5): 521-528.
[11] Zhou Jianpeng,Xie Xudong,Zhao Lei,Wang Jun.. Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis [J]. Int J Stomatol, 2022, 49(5): 586-592.
[12] Chen Huiyu,Bai Mingru,Ye Ling.. Progress in understanding the correlations between semaphorin 3A and common oral diseases [J]. Int J Stomatol, 2022, 49(5): 593-599.
[13] Zhou Jiajia,Zhao Lei,Xu Xin. Research progress on the genetic polymorphism of periodontitis [J]. Int J Stomatol, 2022, 49(4): 432-440.
[14] Zhu Jiani,Su Qin. Research status of the use of root canal and periapical microflora in refractory periapical periodontitis [J]. Int J Stomatol, 2022, 49(3): 283-289.
[15] Ma Yu,Zuo Yu,Zhang Xin. Photodynamic therapy as an adjunct to periodontitis: a meta-analysis [J]. Int J Stomatol, 2022, 49(3): 305-316.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .