Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 680-686.doi: 10.7518/gjkq.2019091

• Reviews • Previous Articles     Next Articles

Axon guidance molecules and their role in oral tissue regeneration

Sun Zhaoze1,2,3,Liu Shuang2,3,Li Shu1,2,3()   

  1. 1. Dept. of Periodontology, School and Hospital of Stomatology, Shandong University, Jinan 250012, China
    2. Shandong Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
    3. Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, China
  • Received:2019-04-19 Revised:2019-08-09 Online:2019-11-01 Published:2019-11-14
  • Contact: Shu Li E-mail:lishu@sdu.edu.cn
  • Supported by:
    This study was supported by Shandong Natural Science Foundation(ZR2019MH006)

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Abstract:

During the development of the nervous system, axon guidance molecules guide the axons to grow along a particular path in a very precise manner. With increasing research on axon guidance molecules and their receptors, results have demonstrated that axon guidance molecules do not only guide axon growth but also participate in angiogenesis, bone regeneration and the development and regeneration of oral tissues through various signalling pathways. Such work provides new ideas for the study and development of treatments for oral diseases. This article reviews the related roles of the four major axon guidance molecules (Slits, Semaphorins, Netrins and Ephrins) in tissue regeneration and oral tissue regeneration.

Key words: axon guidance molecule, tissue regeneration, oral tissue regeneration

CLC Number: 

  • Q136

TrendMD: 
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