Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 687-692.doi: 10.7518/gjkq.2019080

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Role of atomic force microscopy in research on microbial adhesion force

Wang Rui,Gai Kuo,Liu Mengqi,Jiang Li()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-03-21 Revised:2019-07-17 Online:2019-11-01 Published:2019-11-14
  • Contact: Li Jiang
  • Supported by:
    The study was supported by Sichuan Science and Technology Program(2016FZ0069)


As a powerful tool for surface imaging and mechanical detection, atomic force microscopy (AFM) plays an important role in the exploration of microbial morphology and mechanics because of its advantages of nanometre resolution, piconewton force sensitivity and liquid imaging. This paper outlines the latest advances in various imaging modes and force spectroscopies and the cooperation of these technologies based on AFM. It also introduces the applications of AFM in the study of adhesive mechanical properties between bacteria and substrates, bacteria and bacteria, bacteria and bacteria biofilms, thereby providing a new way to research bacteria adhesion mechanics.

Key words: atomic force microscopy, bacterial adhesion, interaction force

CLC Number: 

  • R37


Fig 1

Examples of multiparametric imaging and molecular recognition imaging based on atomic force microscopy[34]"

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