Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (1): 55-58.doi: 10.7518/gjkq.2018.01.011

• Original Articles • Previous Articles     Next Articles

A review on recent developments in pluripotency of gingiva-derived mesenchymal stem cells

Liu Zhenzhen, Fang Jiao, Zhao Jinghui, Zou Jingting, Xiang Xingchen, Wang Jia, Zhou Yanmin   

  1. Dept. of Implantology, Hospital of Stomatology, Jilin University Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China; Dept. of Implantology, Hospital of Stomatology, Jilin UniversityJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2017-05-28 Revised:2017-09-14 Published:2018-01-15
  • Supported by:
    This study was supported by Specialized Research Fund for the Doctoral Program of Higher Education of China (20120061110077), National Natural Science Foundation of China (81200809), Science and Technology Research Project of Jilin Provincial Education Department in 12th Five-Year ([2015]532) and Project Supported by Graduate Innovation Fund of Jilin University (2017014, 2017063).

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Abstract: Mesenchymal stem cells (MSCs) which can be isolated from multiple tissue, have two specific characteristics: self-renewal and multi- or pluripotency. Recent evidence has shown that MSCs also located in gingiva, then be named as gingiva-derived mesenchymal stem cells (GMSCs). GMSCs represent a unique population of MSCs that can be easily isolated and obtained. In addition to maintaining a normal karyotype and telomerase activity in long-term cultures, GMSCs can display a stable phenotype and rapidly proliferate in vitro. Therefore, GMSCs are increasingly become the sources of stem cells for tissue engineering and regenerative medicine research. This review described the research progress of GMSCs’ separation and identification, biological characteristics and differentiation ability and so on.

Key words: mesenchymal stem cells, gingiva-derived mesenchymal stem cells, differentiation, tissue regeneration

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