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Table of Content

    01 January 2018, Volume 45 Issue 1 Previous Issue    Next Issue
    Expert Forum
    Research status and clinical outcomes of zirconia abutments
    Wan Qianbing
    Inter J Stomatol. 2018, 45 (1):  1-8.  DOI: 10.7518/gjkq.2018.01.001
    Abstract ( 980 )   HTML ( 21 )   PDF(pc) (1349KB) ( 923 )   Save
    With the increasing improvement of the living requirements and aesthetic level, as well as the rapid development of oral implantology and computer aided design and computer aided manufacturing (CAD/CAM) technology, the fixed prosthesis which is supported by implant-zirconia abutments has been recognized widely by dentists and patients, due to its excellent aesthetic effect. Compared with the other all-ceramic materials, zirconia has better mechanical properties, except for aesthetic effect, less soft tissue reaction and plaque adhesion and good biocompatibility. Combining the literatures in China and abroad, this paper aims to discuss biological responses to zirconia abutments, clinical biological assessments, mechanical properties of zirconia abutments, aesthetic effect and clinical outcomes of zirconia abutments.
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    Expert Q & A
    Several problems on monolithic zirconia crowns
    Wan Qianbing
    Inter J Stomatol. 2018, 45 (1):  9-13.  DOI: 10.7518/gjkq.2018.01.002
    Abstract ( 1565 )   HTML ( 24 )   PDF(pc) (1317KB) ( 1057 )   Save
    Zirconia restorations have been rapidly used in dentistry for the past few years, owing to their biocompatibility and advantageous mechanical properties. The improvement of computer aided design and computer aided manufacturing (CAD/CAM) technology has enabled the rapid, accurate fabrication of monolithic zirconia crowns. These crowns eliminate the need of the veneering ceramic layer, have superior fracture strength and significantly reduces the occlusal space requirements. It seems reasonable that monolithic zirconia crowns have the potential to be a dominant restorative choice in the posterior tooth region where esthetic concerns are less acute in the future. However, scientific evidence is required to support the application of monolithic zirconia crowns for clinical use. This article reviewed the research progress on mechanical properties, wear behaviors, surface roughness, low temperature degradation, esthetic aspects and short-term clinical researches of monolithic zirconia crowns.
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    Assessment of dental anxiety in patients undergoing surgical procedures for tooth implants
    Chen Qingya, Huang Qian, Wang Li
    Inter J Stomatol. 2018, 45 (1):  14-19.  DOI: 10.7518/gjkq.2018.01.003
    Abstract ( 1094 )   HTML ( 15 )   PDF(pc) (1139KB) ( 532 )   Save

    Objective To evaluate the levels of dental anxiety and its influencing factors in patients undergoing surgical procedures for tooth implants, and to explore the relationship between dental anxiety, state anxiety and trait anxiety. Methods One hundred and twenty-one patients were examined for preoperative anxiety level using modified Cora’s dental anxiety scale (MDAS), dental fear scale (DFS), state-trait anxiety inventory (STAI) before implantation surgery. And the Results were statistically analyzed. Results Prevalence rate of moderate or high dental anxiety (MDAS≥12) was 60.3%, and the mean MDAS score was (12.14±2.44). The differences of anxiety level between groups in gender, income level, self-rated oral health, being initial treatment or not, and if you have a dental implant surgery was statistically significant (P<0.05); the differences of marital status, education level and age was not statistically significant (P>0.05). There was a significant positive correlation between MDAS, DFS and S-AI score (P<0.01), and there was no correlation between T-AI and MDAS, DFS, S-AI score. Conclusion Dental anxiety in patients undergoing surgical procedures for tooth implants was extensive. The level of anxiety was affected by many factors, which was positively correlated with S-AI, and suggesting the necessity of preoperative anxiety intervention in clinical practice.

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    Psychological study of patients undergoing maxillofacial surgery combined with computer-assisted navigation technology
    Duan Limei, Jing Jianlong
    Inter J Stomatol. 2018, 45 (1):  20-25.  DOI: 10.7518/gjkq.2018.01.004
    Abstract ( 860 )   HTML ( 4 )   PDF(pc) (1082KB) ( 205 )   Save

    Objective To study the psychological experience of patients undergoing computer-assisted navigated maxillofacial surgery. Methods Thirty patients who had computer-assisted navigated maxillofacial surgery from October, 2015 to July, 2016 were included into this study. Information from patients were achieved through in-depth interview, and analyzed with Colaizzi method in a qualitative way. Results Based on the interview, 5 themes were identified from the patients studied: 1) anxiety towards the illness and operation; 2) confidence in computer-navigated surgery, but lack in relative knowledge; 3) satisfaction with the treatment provided by the hospital and doctors; 4) satisfaction with the care from the nurses; 5) satisfaction with the surgical outcome. ConclusionWith improved knowledge of surgical navigation, patients showed confidence in this new technology. This suggested detailed introduction was beneficial for these patients. Combined with careful nursing, communication and mental care, successful nursing targets could be achieved.

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    The effects and underlying mechanism of lysophosphatidic acid in β-catenin nuclear translocation of dental pulp cells
    Fang Hongzhi, Yang Hui, Shao Meiying, Hu Tao
    Inter J Stomatol. 2018, 45 (1):  26-31.  DOI: 10.7518/gjkq.2018.01.005
    Abstract ( 669 )   HTML ( 7 )   PDF(pc) (2388KB) ( 300 )   Save

    Objective The aim of our study is to investigate the biological effects of lysophosphatidic acid (LPA) on β-catenin accumulation, activation, and nuclear translocation of cultured human dental pulp cells (DPCs) ex vivo. Methods LPA was used to stimulate dental pulp cells, and Y-27632 was used to inhibit Rho-associated protein kinase (ROCK). Fluorescence microscopy and Western blot were used to detect the effects of Rho/ROCK on β-catenin accumulation, activation, and nuclear transloca- tion. Results β-catenin accumulated around the nuclear membrane after LPA stimulation of DPC for 3 h. When treated for 6 or 10 h with LPA, β-catenin translocated into the nucleus in some dental pulp cells; however, nuclear translocation of β-catenin was abrogated by Y-27632. Results of Western blot showed that LPA promoted β-catenin expression and activation. ROCK inhibition also degraded the level of β-catenin activation. Conclusion LPA regulated β-catenin accumulation, activation, and nuclear translocation via the Rho/ROCK signaling pathway.

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    Original Articles
    Reasearch progress on modified mesoporous bioactive glasses for repairing maxillofacial bone defects
    Wang Yang, Shen Yuqin, Yu Wenwen, Sun Xinhua
    Inter J Stomatol. 2018, 45 (1):  32-35.  DOI: 10.7518/gjkq.2018.01.006
    Abstract ( 902 )   HTML ( 9 )   PDF(pc) (1168KB) ( 555 )   Save
    Mesoporous bioactive glasses is a kind of bioactive material that exhibits a bonding effect with bone tissues. They possess high biocompatibility, biodegradability and good bone formation and conduction properties, which are essential for bone tissue engineering applications. With the aim of increasing their clinical value, researchers in recent years have improved the performance of mesoporous bioactive glasses by reforming their structures. This article provides a brief review on the research progress of modified mesoporous bioactive glasses for maxillofacial bone defect repair.
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    Research progress on multiple endocrine neoplasia type 2
    Zhang Meihua, Hu Ying, Sun Zheng
    Inter J Stomatol. 2018, 45 (1):  36-41.  DOI: 10.7518/gjkq.2018.01.007
    Abstract ( 1053 )   HTML ( 4 )   PDF(pc) (1163KB) ( 465 )   Save

    Multiple endocrine neoplasia type 2 (MEN2) is a rare autosomal dominant disease. This condition can be classified into three types, including MEN2A, MEN2B, and familial medullary thyroid carcinoma (MTC). Primary clinical manifestations of this type of neoplasia include the following: MTC, pheochromocytoma, hyperparathyroidism, Hirschsprung’s disease, bone and facial dysplasia, and multiple nerve fibroma of oral mucosa. MTC contributes mainly to early morbidity and high metastasis rate. Patients with MEN2B are prompted to consult with a dentist primarily due to occurrence of multiple mucosa neuroma. Missense mutations in RET gene result in MEN2. RET is located on chromosome 10. Mutations in genotypes of RET genes correlate with phenotype mutations, including age of onset and degree of malignancy. Clinical experiments determined operation time and plan according to genotype. Gene mutations induces changes in RET gene activities, resulting in changes in intra and extracellular signaling pathways. This paper summarizes research progress on clinical and molecular basis, mechanism of RET gene structure and function changes, and MEN2 diagnosis and treatments.

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    Research progress on single-stranded DNA-binding protein 1
    Zeng Xianglin, Wang Daiyou
    Inter J Stomatol. 2018, 45 (1):  42-45.  DOI: 10.7518/gjkq.2018.01.008
    Abstract ( 1532 )   HTML ( 14 )   PDF(pc) (1148KB) ( 662 )   Save
    Single-stranded DNA-binding protein (SSB) 1 is a newly discovered SSB in humans. Given its involvement in DNA damage repair, SSB1 is critical for genomic integrity and stability. This significant discovery provides new insights into the mechanism of DNA damage repair. In this study, we reviewed the research progress on the structure and function of SSB1.
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    Functions of microRNA on the osteogenic differentiation of human periodontal ligament-derived cells
    Hao Yilin, Fang Fuchun, Wu Buling
    Inter J Stomatol. 2018, 45 (1):  46-49.  DOI: 10.7518/gjkq.2018.01.009
    Abstract ( 935 )   HTML ( 3 )   PDF(pc) (1208KB) ( 237 )   Save
    Human periodontal ligament-derived cells are a group of heterogeneous cells, which can differentiate into osteoblasts, participate in remodeling and repair of alveolar bone remodeling, and periodontal regeneration. MicroRNAs (miRNAs) are thought to play a key role in the regulation of cell differentiation and be key factors in maintaining cell differentiation and regulating differentiation. MicroRNA plays a promotion or inhibition role on osteogenic differentiation by targeting mRNA. In this review, we summarized the different miRNAs in the osteogenic differentiation of periodontal-derived cells, focusing on the function and regulation of target genes and pathways under the mineralized or mechanical force induced conditions.
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    Research progress on strontium in bone tissue engineering
    Zhang Jia, Liu Zhonghao
    Inter J Stomatol. 2018, 45 (1):  50-54.  DOI: 10.7518/gjkq.2018.01.010
    Abstract ( 875 )   HTML ( 8 )   PDF(pc) (1083KB) ( 615 )   Save
    Bone substitute materials are widely used in the process of repairing bone defect, the addition of factors promoting bone regeneration is the main hot spots in the research of bone substitute materials. As a necessary trace element, strontium can simultaneously stimulate new bone formation and reduce bone absorption in vivo. In recent years, many scholars combined strontium with all kinds of bone substitute materials, found that strontium can not only improve the physical and chemical properties of bone substitute materials, but also can change cell behavior, improve the abilities of osteogenesis. This article summarized the above aspects of strontium-doping bone substitute materials.
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    A review on recent developments in pluripotency of gingiva-derived mesenchymal stem cells
    Liu Zhenzhen, Fang Jiao, Zhao Jinghui, Zou Jingting, Xiang Xingchen, Wang Jia, Zhou Yanmin
    Inter J Stomatol. 2018, 45 (1):  55-58.  DOI: 10.7518/gjkq.2018.01.011
    Abstract ( 1206 )   HTML ( 8 )   PDF(pc) (1146KB) ( 759 )   Save
    Mesenchymal stem cells (MSCs) which can be isolated from multiple tissue, have two specific characteristics: self-renewal and multi- or pluripotency. Recent evidence has shown that MSCs also located in gingiva, then be named as gingiva-derived mesenchymal stem cells (GMSCs). GMSCs represent a unique population of MSCs that can be easily isolated and obtained. In addition to maintaining a normal karyotype and telomerase activity in long-term cultures, GMSCs can display a stable phenotype and rapidly proliferate in vitro. Therefore, GMSCs are increasingly become the sources of stem cells for tissue engineering and regenerative medicine research. This review described the research progress of GMSCs’ separation and identification, biological characteristics and differentiation ability and so on.
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    The application of cone-beam computed tomography in implant surgery of maxillary anterior teeth area
    Zhu Chenyou, Deng Jia, Gan Zhoujie, Liu Liu, Wang Tianlu, Cao Cong, Qu Yili
    Inter J Stomatol. 2018, 45 (1):  59-63.  DOI: 10.7518/gjkq.2018.01.012
    Abstract ( 837 )   HTML ( 8 )   PDF(pc) (1082KB) ( 264 )   Save
    In dental implantology, the changes of shapes and dimensions on the alveolar ridge have great impacts on the implant success rate. Moreover, the height and width of the alveolar ridge are crucial indexes in implant placement. Cone-beam computed tomography is usually used to obtain the 3-dimensional images and measurements of the alveolar ridge. However, the 3-dimentional structure of the alveolar ridge is complex and has shape diversity. Therefore, there are different methods of measurement and various standards of classification in the studies. The upper anterior teeth are common surgical sites in dental implant surgery. Therefore, in the present study we review several methods of measurement and classification of the upper anterior teeth,in order to provide a reference for proper planning before implantation and clinical research.
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    Cleidocranial dysplasia and dentofacial characterization
    Qian Haoliang, Li Sheng, Jiang Hongbing
    Inter J Stomatol. 2018, 45 (1):  64-67.  DOI: 10.7518/gjkq.2018.01.013
    Abstract ( 1185 )   HTML ( 18 )   PDF(pc) (1146KB) ( 562 )   Save
    Cleidocranial dysplasia (CCD) is a hereditary skeletal system disease characterized by autosomal dominant inheritance and rare clinical manifestations. The main cause of CCD was RUNX2 heterozygous mutation gene. In this paper, CCD were reviewed from the following aspects: 1) clinical manifestation, clinical diagnosis and molecular diagnosis of CCD; 2) oral manifestations and corresponding pathogenesis of CCD; 3) treatment of oral representation of CCD.
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    Clinical applications of subepithelial connective tissue grafting in soft tissue deficiencies of dental implantation
    Wan Shuangquan, Deng Feilong
    Inter J Stomatol. 2018, 45 (1):  68-73.  DOI: 10.7518/gjkq.2018.01.014
    Abstract ( 816 )   HTML ( 4 )   PDF(pc) (1634KB) ( 408 )   Save
    The condition of peri-implant soft tissue is closely related to the outcome of dental implant. However, many problems concerning soft tissue defects may occur after dental implantation. Subepithelial connective tissue grafting is a common technique for soft tissue augmentation in clinical practice and solution to many problems of soft tissue deficiency in oral treatment. This review summarized the donor sites and histological characteristics of corresponding grafts, harvesting techniques, recipient site preparation techniques, clinical effects and development directions of subepithelial connective tissue grafting.
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    Research progress on polylactic acid post for the repairment of residual crown and root in deciduous teeth
    Wang Chunyan, Zhang Kun, Jiang Songlei
    Inter J Stomatol. 2018, 45 (1):  74-77.  DOI: 10.7518/gjkq.2018.01.015
    Abstract ( 1008 )   HTML ( 23 )   PDF(pc) (1110KB) ( 695 )   Save
    The deciduous teeth play an important role in the process of children’s growth and development. The residual crown and residual root of it is a key problem for clinical treatment, which can only be choosed to suit the processing or pull out. Along with the development of medical materials, the polylactic acid (PLA) is widely used in clinical treatment because of its good biocompatibility, excellent physical and chemical properties of the human body without poison, and can be degraded and excreted in the form of carbon dioxide and water. The application of PLA post for its repair provides a broad prospect. This article summarizes the physical and chemical properties, biocompatibility, indication and clinical application status of the PLA post.
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    The current state of physicochemical properties and biological performance researches on iRoot SP
    Peng Li, Wang Zuhua
    Inter J Stomatol. 2018, 45 (1):  78-84.  DOI: 10.7518/gjkq.2018.01.016
    Abstract ( 4480 )   HTML ( 182 )   PDF(pc) (1185KB) ( 2426 )   Save
    The clinical effects and prognosis of root canal treatment have close relation to the type of the root canal sealer. iRoot SP is a new bioceramic root canal sealer, has been recommended for endodontic obturation because of its superior physicochemical properties and biological performance. The related studies are focused on the characters of iRoot SP. The essay mainly summarizes the current state of physicochemical properties and biological performance research on iRoot SP.
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    Robotic surgery in craniofacial non-malignant diseases
    Liu Hanghang, Luo En
    Inter J Stomatol. 2018, 45 (1):  85-90.  DOI: 10.7518/gjkq.2018.01.017
    Abstract ( 710 )   HTML ( 5 )   PDF(pc) (1103KB) ( 361 )   Save
    Robotic surgery has been used in oral surgical procedures since 21th century, including head and neck cancer as well as non-malignant diseases. This article covers the inception to current application to speculation of robotic technology in complex area of craniofacial non-malignant diseases.
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    Research progress on tooth autotransplantation combined with orthodontic treatment
    Li Jinjin, Pan Jian
    Inter J Stomatol. 2018, 45 (1):  91-96.  DOI: 10.7518/gjkq.2018.01.018
    Abstract ( 1018 )   HTML ( 25 )   PDF(pc) (1153KB) ( 588 )   Save
    Tooth autotransplantation is an alternative therapeutic option for replacing the missing teeth in clinic. With the understanding of various prognosis factors, it has achieved higher survival rate. In recent years, the combination with orthodontic treatment not only extends the clinical application range, at the same time, it helps to reduce the incidence of root absorption and ankylosis of autotransplanted tooth. The purpose of this article is to review the prognosis factors influencing the success of autotransplanted tooth and the combination with orthodontic treatment.
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    Research progress on ultrasonic instruments applied in refined margin shoulder preparation
    Tian Bin, Li Yuxuan, Yu Na
    Inter J Stomatol. 2018, 45 (1):  97-99.  DOI: 10.7518/gjkq.2018.01.019
    Abstract ( 715 )   HTML ( 7 )   PDF(pc) (1066KB) ( 310 )   Save
    In recent years, ultrasonic instruments have been applied for margin shoulder refining with higher standard raised in fixed prosthesis. It’s excellent effects in smoothing margin shoulder complied with the precision trend. While the in vitro research occupied an predominant position in relevant aspects. This article was written to conduct a retrospective analysis and develop future tendency on application of ultrasonic instruments in margin shoulder perfection.
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    Clinical research progress on lingual orthodontic techniques
    Jing Xuan, Wu Xiuping, Wang Jun
    Inter J Stomatol. 2018, 45 (1):  100-105.  DOI: 10.7518/gjkq.2018.01.020
    Abstract ( 766 )   HTML ( 9 )   PDF(pc) (1093KB) ( 302 )   Save
    In recent years, lingual orthodontic treatment is gradually favored by patients, which can provide many advantages such as good appearance, accurate position and wider indications. It must bring higher requests to the diagnosis and treatment of doctors, because the biomechanical mechanism of lingual orthodontic treatment is obviously different from the traditional labial orthodontic treatment. In this paper, lingual orthodontics was reviewed about the development, types, characteristics, biomechanical mechanism and clinical applications.
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    Research progress on esthetics of buccal corridor
    Xie Yijia, Zou Xunming, Xu Xiaomei, Lin Fuwei, Zhao Qing
    Inter J Stomatol. 2018, 45 (1):  106-111.  DOI: 10.7518/gjkq.2018.01.021
    Abstract ( 855 )   HTML ( 13 )   PDF(pc) (1090KB) ( 423 )   Save
    Smile esthetics has been popular in the domestic and overseas orthodontic academia for a long time. The studies of smile esthetics have developed from static esthetics to dynamic esthetics. Buccal corridor, as an important part of smile esthetics, has been realized by more and more orthodontists and even laypeople. Only on the basis of full understanding about the professional knowledge of buccal corridor esthetics and mastering the orthodontic methods to change the size of buccal corridor, orthodontists can help patients get more beautiful smile. Thus, we would make a review on the definition and research methods of buccal corridor, the influencing factors on the size and esthetic effect of buccal corridor, hoping to provide references of orthodontists’ clinical decision.
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    A three-dimensional finite element analysis for stability of mini-implant anchorage
    Zeng Tingyan, Huang Shenggao
    Inter J Stomatol. 2018, 45 (1):  112-118.  DOI: 10.7518/gjkq.2018.01.022
    Abstract ( 744 )   HTML ( 7 )   PDF(pc) (1172KB) ( 450 )   Save
    Mini-implant anchorage for the orthodontic treatment is an effective method to reinforce anchorage. The stability is critical in the achievement of reliable anchorage. Three-dimensional finite element analysis is one of the most effective method to analyze biomechanics and simulate stomatognathic system, which has been widely used in orthodontic research. We summarized the current literature on the use of the three-dimensional finite element method in primary stability of mini-implant anchorage from aspects of mini-screw implants, bone and operation, in order to improve success of implant.
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    Application of 3D printing in oral and maxillofacial surgery education
    Wang Ke, Xiang Tao, Tang Yaling, Liang Xinhua
    Inter J Stomatol. 2018, 45 (1):  119-124.  DOI: 10.7518/gjkq.2018.01.023
    Abstract ( 671 )   HTML ( 12 )   PDF(pc) (1159KB) ( 488 )   Save
    3D printing technique, a rapid prototyping technique, which is developing fast, has already been used in oral and maxillofacial clinical surgery. At the same time, 3D printing model is playing a more and more important role in the education field. This review focuses on the application of 3D printing to oral and maxillofacial surgery education.
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