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Table of Content

    01 March 2018, Volume 45 Issue 2 Previous Issue    Next Issue
    Expert Forum
    Diagnosis and clinical treatment of labial injury of systemic diseases
    Wang Zhi
    Inter J Stomatol. 2018, 45 (2):  125-131.  DOI: 10.7518/gjkq.2018.02.001
    Abstract ( 957 )   HTML ( 15 )   PDF(pc) (1704KB) ( 326 )   Save
    Oral mucosa lesions are the common manifestations of a variety of systemic diseases, some of these diseases can be major or specific skin involvement lip and around the lips, so this paper reviewed the main systemic diseases affected lip and around the lips, in order to guide the clinical doctor get a thorough history and physical examination, then to accurately determine the etiology of lip lesion, and receive better treatment effect.
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    Case Display
    Thinking on a case of atypical performance of acquired immure deficiency syndrome
    Meng Wenxia, Jiang Liyi, Lai Yanqun, Yao Yanmei
    Inter J Stomatol. 2018, 45 (2):  132-134.  DOI: 10.7518/gjkq.2018.02.002
    Abstract ( 769 )   HTML ( 16 )   PDF(pc) (3466KB) ( 449 )   Save
    This article reported about a patient with acquired immune deficiency syndrome and recurrent aphthous ulcers. Possible reasons of misdiagnosis were also discussed.
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    Oral Medicine
    Clinical significance of CD20 expression in oral potentially malignant disorders
    Liu Yi, Zhou Hao, Fei Wei
    Inter J Stomatol. 2018, 45 (2):  135-139.  DOI: 10.7518/gjkq.2018.02.003
    Abstract ( 1112 )   HTML ( 10 )   PDF(pc) (6999KB) ( 196 )   Save
    Objective This study aims to investigate the expression of C20 in oral potentially malignant disorders (OPMDs) by using the histological analysis and evaluates the clinical value of using CD20 as indices to assess the carcinogenic potential of OPMDs.Methods Clinical data from 17 cases with oral hyperplasia mucosa, 21 cases with oral lichen planus (OLP), 15 cases with mild oral dysplasia mucosa (D1), and 9 cases with mild moderate dysplasia mucosa (D2) were analyzed by using retrospective analysis. Immunohistochemical analysis was applied to investigate the expression of CD20 in paraffin sections of oral hyperplasia mucosa, OLP, D1, and D2 tissues. Subsequently, the relationships between such expression and clinical factors were investigated.Results Results The positive rates of CD20 expression in the oral hyperplasia mucosa, OLP, D1, and D2 mucosa were 11.76%, 61.90%, 20.00%, and 66.67% (P<0.05), respectively. CD20 expression was found uncorrelated with age, gender, region, alcohol use, and smoking status (P>0.05). The multiple-factor analysis showed that the odds ratios of OLP and D2 significantly increased (P<0.05) when oral hyperplasia mucosa was used as the reference group. Conclusion CD20 may be used individually as clinical index to evaluate the carcinogenic potential of OPMDs.
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    Adverse reactions of targeted anticancer agents in oral cavity: manifestation and management
    Xiao Yandi, Yang Huamei, Dan Hongxia
    Inter J Stomatol. 2018, 45 (2):  140-144.  DOI: 10.7518/gjkq.2018.02.004
    Abstract ( 2296 )   HTML ( 14 )   PDF(pc) (1117KB) ( 464 )   Save
    Targeted therapy is widely used in cancer treatment. However, anticancer agents used in targeted therapy can induce various adverse reactions in oral cavity. This review aims to summarize the adverse reactions in oral cavity incurred during targeted therapy and the corresponding strategies for their management.
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    Research progress on the etiology of recurrent aphthous ulcer in children
    Cai Donglin, Lu Rui
    Inter J Stomatol. 2018, 45 (2):  145-149.  DOI: 10.7518/gjkq.2018.02.005
    Abstract ( 1158 )   HTML ( 14 )   PDF(pc) (1156KB) ( 391 )   Save
    Recurrent aphthous ulcer (RAU) is the most common ulcerative disease of the oral mucosa. Although RAU appears in all ages, the onset of RAU peaks during childhood. Childhood RAU, as a special patient group, displays distinct etiology. The etiology of childhood RAU includes genetic, local trauma, psychologic, nutritional factors, microbial infection, and abnormal immunologic response. Moreover, some cases of childhood RAU are associated with several systemic diseases. This article presents the current progress on the etiology of RAU in children.
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    Research progress on burning mouth syndrome
    Yin Xi, Sun Zheng
    Inter J Stomatol. 2018, 45 (2):  150-154.  DOI: 10.7518/gjkq.2018.02.006
    Abstract ( 1200 )   HTML ( 11 )   PDF(pc) (1179KB) ( 746 )   Save
    Burning mouth syndrome (BMS) is a group of syndromes mainly located in the tongue. This syndrome is characterized with burning pain without any visible clinical sign. BMS often develops in perimenopausal women. No uniform diagnostic criteria, clear etiology, or effective treatment method for BMS is available to date. This review introduces the epidemiology, diagnostic criteria, classification, etiology, and treatment of BMS.
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    Immunosuppressive adjuvant therapy for pemphigus
    Yao Yihuan, Wang Jiongke, Zhao Kui, Shi Yujie, Zeng Xin, Chen Qianming
    Inter J Stomatol. 2018, 45 (2):  155-161.  DOI: 10.7518/gjkq.2018.02.007
    Abstract ( 1220 )   HTML ( 15 )   PDF(pc) (1232KB) ( 664 )   Save
    Pemphigus is a severe, chronic, autoimmune bullous disease that affects the skin and mucous membranes. To date, glucocorticoidis the first treatment medicine for pemphigus. Nevertheless, the use of glucocorticoid may result in adverse effects during treatment of this disease. Therefore, several immunosuppressive adjuvant therapies or non-medicinal therapies should be adopted to relieve the side effects of glucocorticoid. Thus, we reviewed the immunosuppressive therapy in this article.
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    Adjuvant therapy for pemphigus in addition to glucocorticoid and immunosuppressor
    Yao Yihuan, Wang Jiongke, Zeng Xin, Chen Qianming
    Inter J Stomatol. 2018, 45 (2):  162-169.  DOI: 10.7518/gjkq.2018.02.008
    Abstract ( 730 )   HTML ( 7 )   PDF(pc) (1214KB) ( 409 )   Save
    Pemphigus is a severe, chronic, autoimmune bullous disease affecting the skin and mucous membranes. Recently, glucocorticoid and immunosuppressor are the most common treatments for pemphigus. However, these treatment may result in unfavorable effects, such as hypertension and marrow suppression, during treatment. Thus, the combination of other treatments with glucocorticoid and (or) immunosuppressor should be evaluated according to the patients’ condition. In this article, we reviewed the non-glucocorticoid and non-immunosuppressor therapy.
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    Original Articles
    Establishment of diabetic mouse model with conditional knockout of FoxO1 in osteoblasts
    Xiong Yi, Gong Ping, Wu Yingying
    Inter J Stomatol. 2018, 45 (2):  170-176.  DOI: 10.7518/gjkq.2018.02.009
    Abstract ( 774 )   HTML ( 7 )   PDF(pc) (1529KB) ( 313 )   Save
    Objective This study aims to establish a diabetic mouse model with conditional knockout of FoxO1 in osteoblasts and preliminary explore the phenotypes.Methods Wild type (WT) and gene knockout mice were obtained according to the designed reproductive strategy. DNA was extracted from mouse tail and amplified by real-time polymerase chain reaction (RT-PCR). The mice phenotypes were also detected. The mRNA and protein levels of FoxO1 in osteoblasts and other tissues were obtained and detected by RT-PCR and Western blot analysis. Mice weight and fasting blood glucose were measured. Insulin tolerance test (ITT) was conducted to assess the role of FoxO1 in glucose metabolism. Results Diabetic mouse models with conditional knockout of FoxO1 in osteoblasts were successfully established. The body weight of diabetic mice was significantly lower than that of normal mice at 2 weeks. The fasting blood glucose in diabetic gene knockout mice was lower than that in diabetic WT mice. In addition, ITT showed that FoxO1 knockout promoted insulin sensitivity in diabetic gene knockout mice compared with that in diabetic WT mice.Conclusion Diabetic mouse model with conditional knockout of FoxO1 in osteoblasts was successfully established. FoxO1 knockout ameliorated hyperglycaemia, which may be accounted for the increased insulin sensitivity in diabetic gene knockout mice.
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    Reliability and validity of the velopharyngeal insufficiency effects on life outcomes instrument
    Huang Hanyao, Wang Mengjiao, Wu Hao, Jiang Liping, Zhang Wenjing, Wei Shan, Yin Heng
    Inter J Stomatol. 2018, 45 (2):  177-184.  DOI: 10.7518/gjkq.2018.02.010
    Abstract ( 1079 )   HTML ( 9 )   PDF(pc) (1251KB) ( 457 )   Save
    Objective In this study, we aim to translate the original English version of the velopharyngeal insufficiency effects on life outcomes instrument (VELO) into Chinese and test the psychometric properties of VELO among eligible Chinese patients with velopharyngeal insufficiency (VPI).Methods The original English version of VELO was translated, back-translated, and adapted among different cultures. Based on the standard procedures of the International Quality of Life Assessment (IQoLA) project, VELO was established for self-assessment by patients and assessment by caregivers. The reliability and validity of our translated VELO were assessed in Chinese patients with VPI and their caregivers.Results A total of 366 questionnaires were completed, 211 of whichwere completed by patients and 155 by caregivers. In addition, 362 (98.91%) valid questionnaires were collected, comprising 109 questionnaires from the patients in the experimental group, 99 from the patients in the control group, 66 from the caregivers in the experimental group, and 88 from the caregivers in the control group. The cronbach’s α of VELO for a patient with VPI was 0.937, and that of a caregiver was 0.950. Meanwhile, the Guttman split-half reliability coefficient of a patient with VPI was 0.908, and that of a caregiver was 0.887. After the content was validated, the items had intermediate or high correlation with corresponding domains. The patients with VPI and control patients were effectively discriminated through VELO, indicating that the results reached the IQoLA standard. The same result was obtained in the caregivers.Conclusion The translated Chinese version of VELO has acceptable reliability and validity. These psychometric properties provide theoretical evidence for further use of VELO in Chinese patients with VPI.
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    Reviews
    Effects of melatonin regulating on growth and development of hard tissues
    Chen Haoling, Lin Yujing, Zhu Hui, Yang Tingting, Huang Fang
    Inter J Stomatol. 2018, 45 (2):  185-191.  DOI: 10.7518/gjkq.2018.02.011
    Abstract ( 1258 )   HTML ( 6 )   PDF(pc) (1239KB) ( 578 )   Save
    The function and mechanism of melatonin are current research focus. A number of studies showed that melatonin can promote the proliferation and differentiation of osteoblasts, thereby inhibiting the activity of osteoclasts and inducing the differentiation of bone mesenchymal stem cells into osteoblasts. Melatonin can also inhibit the proliferation of dental papilla cells and promote their differentiation. Melatonin is closely related with teeth and bone diseases. The mechanism may be associated with melatonin receptors and their functional pathways. In this review, we summarise the effects of melatonin on hard tissue and its potential mechanism.
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    Application of nano-hydroxyapatite in the clinical treatment of oral diseases
    Luo Weidan, Li Mingyun, Zhou Xuedong, Cheng Lei
    Inter J Stomatol. 2018, 45 (2):  192-198.  DOI: 10.7518/gjkq.2018.02.012
    Abstract ( 924 )   HTML ( 15 )   PDF(pc) (1204KB) ( 351 )   Save
    Nano-hydroxyapatite (nHA) shows a structure similar to that of hydroxyapatite crystal in human bone tissue and tooth enamel. Given its excellent physical and chemical properties, biocompatibility and osseointegration, nHA has been extensively applied in the clinical treatment of oral diseases. This article reviewed the most recent findings about nHA in stomatology, including the modification of restorative materials, tooth remineralization, tooth desensitization, pulp canal therapy and pulp tissue engineering. These studies are indicative of the future remarkable significance of nHA in stomatology.
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    Research progress on the relevance between drug-induced gingival overgrowth and cell proliferation and apoptosis
    Zhan Yeming, Zhang Mingzhu
    Inter J Stomatol. 2018, 45 (2):  199-203.  DOI: 10.7518/gjkq.2018.02.013
    Abstract ( 736 )   HTML ( 9 )   PDF(pc) (1185KB) ( 131 )   Save
    Patients who received a long-term drug therapy, including calcium channel blockers, antiepileptic and immunosuppressive drugs, often suffered from drug-induced gingival overgrowth (DIGO). However, the pathogenesis of DIGO remains unclear to date. A number of research found that DIGO is relevant to apoptosis and cell proliferation. Research progress on the relevance between drug-induced gingival overgrowth and the apoptosis and cell proliferation is summarised in this paper.
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    Matrix vesicles and their relationship with cytoskeleton-associated proteins
    Xian Xuehong, Jiang Hongwei
    Inter J Stomatol. 2018, 45 (2):  204-208.  DOI: 10.7518/gjkq.2018.02.014
    Abstract ( 999 )   HTML ( 10 )   PDF(pc) (1184KB) ( 281 )   Save
    Matrix vesicles are small vesicles closely associated with mineralisation. During the formation and mineralisation of matrix vesicles, most functions are closely related to their own proteins. This article aims to review the research progress on matrix vesicles, their extraction and purification and proteomic and cytoskeleton-associated proteins related to secretion. Understanding the functions of related proteins and the underlying mechanisms contributes in providing theoretical basis for clinical research on mineralisation.
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    Cytotoxic mechanism of triethylene glycol dimethacrylate
    Chen Xiuchun, Zhang Zhimin, Hong Lihua, Zhang Yaqi, Zheng Peng, Li Wenyue
    Inter J Stomatol. 2018, 45 (2):  209-213.  DOI: 10.7518/gjkq.2018.02.015
    Abstract ( 659 )   HTML ( 5 )   PDF(pc) (1246KB) ( 140 )   Save
    Cell toxicity is a pure cell killing event caused by a cell or chemical substances. The chemical substances act on the basic structure of the cell and/or physiological processes, such as cell membrane and cytoskeleton structure, cell metabolism, synthesis of cellular components or products, degradation or release, ion regulation and cell division. Which leads to adverse reactions such as cell survival, proliferation and/or functional disorder. Triethylene glycol dimethacrylate (TEGDMA) is a commonly used diluent of many resin-based dental composites. It is an important relevant monomer responsible for the cytotoxicity of the resin matrix. The monomer can lead to a series of toxic reactions, such as oxidative imbalance, apoptosis, DNA damage and so on. In this paper, the research advances in mechanism of cytotoxicity induced by TEGDMA monomer is reviewed, the aim is to lay the foundation for further clarifying the mechanism of toxicity and to reduce or eliminate the toxic effect.
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    Pathogenesis and clinical management of apical periodontitis in diabetic patients
    Yi Xiaowei, Huang Dingming, Zhang Lan
    Inter J Stomatol. 2018, 45 (2):  214-218.  DOI: 10.7518/gjkq.2018.02.016
    Abstract ( 940 )   HTML ( 9 )   PDF(pc) (1181KB) ( 514 )   Save
    Diabetes mellitus considerably affects the occurrence, development and prognosis of apical periodontitis. Recently, numerous studies have been conducted to determine the underlying mechanism. In this paper, the pathogenesis and the clinical management of apical periodontitis in diabetic patients are reviewed.
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    Research progress on the pathogenesis of non-syndromic tooth agenesis
    Zhang Feng, Ouyang Shaobo, Liao Lan
    Inter J Stomatol. 2018, 45 (2):  219-223.  DOI: 10.7518/gjkq.2018.02.017
    Abstract ( 766 )   HTML ( 8 )   PDF(pc) (1180KB) ( 321 )   Save
    Tooth agenesis is a common phenomenon of tooth number abnormity. Non-syndromic tooth agenesis is the tooth development process without other systemic syndromes of tooth agenesis. Previous studies mainly focused on the genes. However, the pathogenesis of non-syndromic tooth agenesis is few and scattered. This article provides a summary regarding the pathogenesis of non-syndromic tooth agenesis.
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    Relationship between herpes virus and periodontitis
    Zheng Zhi, Yan Shiguo
    Inter J Stomatol. 2018, 45 (2):  224-227.  DOI: 10.7518/gjkq.2018.02.018
    Abstract ( 1102 )   HTML ( 6 )   PDF(pc) (1148KB) ( 556 )   Save
    Herpes virus is common in nature and closely related to periodontitis. Herpes virus is widespread in the oral cavity of patients with chronic periodontitis, aggressive periodontitis. Herpes virus plays a role in periodontitis by direct damage to cells, interfere with host immune system, and establishing a co-relationship with periodontal pathogens. Hereby, the researches between herpes virus and periodontitis were reviewed.
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    Application and research progress on virtual articulator
    Zhan Danting, Zhang Fan, Zheng Lige
    Inter J Stomatol. 2018, 45 (2):  228-232.  DOI: 10.7518/gjkq.2018.02.019
    Abstract ( 1850 )   HTML ( 48 )   PDF(pc) (1160KB) ( 1050 )   Save
    Along with the advancement in digital technology, virtual articulator, a combination between modern computer technology and gnathology, has become a topic of great interest among researchers world wide. The use of traditional articulator is complicated and thus accurately simulatingthe movement of a three-dimensional stomatognathic system is difficult. Nevertheless, the virtual articulator is expected to generate precise simulations of various functions of stomatognathic systems through computer-aided designs. In this paper, we reviewed the developments regarding virtual articulator applications.
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    Research progress on the digital template for root canal location
    Lü Jing, Ling Junqi
    Inter J Stomatol. 2018, 45 (2):  233-238.  DOI: 10.7518/gjkq.2018.02.020
    Abstract ( 1149 )   HTML ( 17 )   PDF(pc) (3692KB) ( 701 )   Save
    Root canal treatment is necessary when apical periodontitis occurs in teeth with pulpal obliteration or dens invaginatus. Determining the accurate location of root canal and the path of preparation is one of the most common challenges in clinical practice. Digital template based on cone beam-computed tomography, digital design software, and 3D printing allows a minimal invasive access and location of root canal and thus preserves tooth structures and improves the success rate of root canal therapy. In this review, we summarized the background, current developments, manufacture method, accuracy, and clinical application of digital templates for root canal location.
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    Clinical research progress on simultaneous crestal sinus floor lift and dental implant placement without bone graft
    Yan Mingdong, Xia Haibin, Wang Min
    Inter J Stomatol. 2018, 45 (2):  238-244.  DOI: 10.7518/gjkq.2018.02.021
    Abstract ( 950 )   HTML ( 11 )   PDF(pc) (1174KB) ( 414 )   Save
    In recent years, an increasing number of researchers have started focusing on crestal sinus floor lift without bone graft. This method has several advantages, such as the absence of bone graft material, short duration, low cost, and easy acceptance of patients. Our article is a review regarding the clinical application of crestal sinus floor lift and simultaneous dental implant placement without bone graft and related researches.
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    Mechanism of vertical food impaction
    Wang Maoxia, Dai Guanyu, Meng Yukun
    Inter J Stomatol. 2018, 45 (2):  245-248.  DOI: 10.7518/gjkq.2018.02.022
    Abstract ( 1045 )   HTML ( 23 )   PDF(pc) (1145KB) ( 483 )   Save
    Vertical food impaction, defined as the forceful wedging of food into the interproximal space by chewing pressure, leads to mechanical stimulation and bacterial colonization, results in discomfort in food impaction areas, even caries and periodontal diseases. Food impaction channel between adjacent teeth during function is the key point in vertical food impaction. Focusing on physiological proximal contacts, we postulated the mechanism of vertical food impaction.
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