Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (2): 199-203.doi: 10.7518/gjkq.2018.02.013

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Research progress on the relevance between drug-induced gingival overgrowth and cell proliferation and apoptosis

Zhan Yeming, Zhang Mingzhu   

  1. Dept. of Periodontics, Stomatological Hospital, Kunming Medical University, Kunming 650000, China
  • Received:2017-09-25 Revised:2017-12-20 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by Joint Project of Application Fundamental Research, Science and Technology Department, Yunnan Province and Kunming Medical University (2014FZ039).

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Abstract: Patients who received a long-term drug therapy, including calcium channel blockers, antiepileptic and immunosuppressive drugs, often suffered from drug-induced gingival overgrowth (DIGO). However, the pathogenesis of DIGO remains unclear to date. A number of research found that DIGO is relevant to apoptosis and cell proliferation. Research progress on the relevance between drug-induced gingival overgrowth and the apoptosis and cell proliferation is summarised in this paper.

Key words: drug-induced gingival overgrowth, cell proliferation, apoptosis, inflammation

CLC Number: 

  • R781.4+1

TrendMD: 
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