Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 191-196.doi: 10.7518/gjkq.2019020

• Periodontal Diseases • Previous Articles     Next Articles

Biological function of amelogenin during periodontal regeneration

Yuxuan Yang,Haixia Zhang,Shuang Wang()   

  1. Dept. of Orthodontics, Hospital of Stomatology, Xi’an Jiaotong University, Xi’an 710004, China
  • Received:2018-06-25 Revised:2018-11-07 Online:2019-03-01 Published:2019-03-15
  • Contact: Shuang Wang E-mail:wshuang@xjtu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81200822)

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Abstract:

Recovery of the lost bone tissue of periodontitis patients is the ultimate purpose of periodontic clinical treatment. Enamel matrix proteins (EMPs) are widely used in periodontal regeneration treatment and lead to an appealing outcome. Amelogenin (AML) is the major component of EMPs with multiple biological effects on periodontal regeneration progress. However, the mechanism of this progress is still unclear. The signal pathway by which AML may be triggered during bone regeneration is still under investigation. In this study, we attempt to discuss the function of AML in cell attachment, migration, proliferation and differentiation during periodontal regeneration and try to explain possible mechanisms underlying such progress.

Key words: amelogenin, enamel matrix protein, cell attachment, cell migration, cell proliferation, cell differentiation

CLC Number: 

  • Q813

TrendMD: 

Fig 1

Grp78 mediated endocytosis"

Fig 2

Wnt/β-catenin pathway"

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