Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (5): 586-591.doi: 10.7518/gjkq.2015.05.025

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Mechanisms of c-Jun N-terminal kinase signal transduction pathway regulating cell migration

Tan Xiujun, Ye Ling, Wang Chenglin   

  1. State Key Laboratory of Oral Diseases, Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2015-03-18 Revised:2015-06-10 Online:2015-09-01 Published:2015-09-01

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Abstract:

C-Jun N-terminal kinase(JNK) is a member of the mitogen-activated protein kinase family, which regulates diverse cellular programs by relaying extracellular signals to intracellular responses. Activated primarily by cytokines and environmental stress, the JNK signal transduction pathway regulates cell migration and plays an important role in cellular proliferation, differentiation, inflammatory response, and apoptosis. The mechanism of cell migration is closely related to the cytoskeleton, focal adhesion, focal adhesion kinase, integrin, and ras homology oncogene family proteins, G-protein, and aquaporin. Recent research on JNK pathway regulating cell migration shows that the activation of the JNK signaling pathway can promote epithelial cell and fibroblast migration and can enhance wound healing and tissue repair. Inhibiting the JNK signaling pathway can reduce cell migration and invasion in tumor cells. The function and mechanism of JNK in inflammation are controversial. Discovering the specific mechanisms underlying the activities of the JNK signal transduction pathway, which is involved in regulating cell migration, can provide new ideas for tissue repair, inflammation control, and tumor treatment.

Key words: c-Jun N-terminal kinase, cell migration, signal transduction


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