Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 197-202.doi: 10.7518/gjkq.2019024

• Periodontal Diseases • Previous Articles     Next Articles

Research progress on cathepsins related to periodontitis

Ran Nie,Tianqi Guo,Xue Li,Tingting Pei,Qin Qin,Yanmin. Zhou()   

  1. Dept. of Dental Implantology, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2018-06-13 Revised:2018-12-10 Online:2019-03-01 Published:2019-03-15
  • Contact: Yanmin. Zhou E-mail:Zhouym62@163.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81570983)

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Abstract:

Cathepsin series, also known as proteolysis enzymes in the lysosome, have received attention for their pathology in systemic diseases such as tumour, osteoporosis and rheumatoid arthritis. Many studies have shown that cathepsins are also closely related to the occurrence and progression of periodontitis. Therefore, research on cathepsins towards clinical precaution and alleviation of periodontitis is of great importance. This article reviews the structures, functions, pathogenesis and relevant inhibitors of cathepsins K, B, C and G which are associated with periodontitis.

Key words: periodontitis, cathepsin, cathepsin inhibitor, nuclear factor

CLC Number: 

  • R781.4 +2

TrendMD: 
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