Int J Stomatol

Inter J Stomatol ›› 2016, Vol. 43 ›› Issue (2): 207-211.doi: 10.7518/gjkq.2016.02.020

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Inhibition and induction on the differentiation of periodontal ligament stem cells in different microenvironments

Pan Youtiao1, Wang Yifei2, Zhao Xun3, Zeng Xianzhuo3, Zhang Zhen1, Cheng Junjun1, Li Xianing1, Liu Wei1, Zhao Hongyu4   

  1. 1. Dept. of Periodontics, Hospital of Stomatology, Zhengzhou University, Zhengzhou 450000, China; 2. School of Life Sciences, Jinan University, Guangzhou 510000, China; 3. Shenzhen IStem Regenerative Medicine Sci-Tech Limitied Company, Shenzhen 518000, China; 4. Center of Special Diagnosis, Stomatological Hospital of Guangdong Province, Guangzhou 511400, China)
  • Received:2015-07-24 Revised:2015-10-28 Online:2016-03-01 Published:2016-03-01

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Abstract: Periodontal ligament stem cells(PDLSC), basic cells in the new treatment strategy for periodontal regeneration, perform a triggering function in regeneration after periodontal defect and the maintenance of periodontal dynamic equilibrium. Based on basic research and preclinical studies, as well as clinical trials, PDLSC would show different proliferation and differentiation in different microenvironment. PDLSC niche and inflammation could inhibition differentiation, whereas the microenvironment of dentin and developmental apex could show promotion. Therefore, the effects of different microenvironments on PDLSC may open the access of biological function and present theoretic foundation for periodontal regeneration. Therefore, this review focuses on the features and functional mechanisms of periodontal microenvironments and adds further insight into the use of PDLSC preparation as viable therapy for periodontal regeneration.

Key words: periodontal, periodontal ligament stem cell, microenvironment, cell differentiation, periodontal, periodontal ligament stem cell, microenvironment, cell differentiation

CLC Number: 

  • Q 254

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