Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (1): 94-97.doi: 10.7518/gjkq.2013.01.024

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Research progress on pathogenesis of dental fluorosis

Liu Panlong1 , Zhou Hongyan2 , Wang Dongmiao3 , Mei Yufeng1.   

  1. 1. Dept. of Preventive Dentistry, The Stomatological Hospital of Xuzhou City, Xuzhou 221002, China; 2. Dept. of Pediatric Dentistry, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing 210029, China; 3. Dept. of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing 210029, China
  • Received:2012-03-20 Revised:2012-10-12 Online:2013-01-01 Published:2013-01-01

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Abstract:

The fluorine is a master morbigenous factor of dental fluorosis and plays a role in all stages of enamel formation. The influence of fluoride on amelogenesis, which includes the cell toxicity of fluorine, the influence of enamel matrix protease and the mineralized processes, are reviewed in this article. The correlated mechanism of dental fluorosis was also discussed.

Key words: dental fluorosis, cytotoxicity, amelogenin, matrix metalloproteinase, mineralization


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