Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (6): 732-738.doi: 10.7518/gjkq.2020089

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Research progress on tea polyphenols in dentin adhesion

Liu Enyan(),Li Mingyun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-02-05 Revised:2020-05-28 Online:2020-11-01 Published:2020-11-06
  • Contact: Mingyun Li E-mail:liuenyanAPTX@163.com;limingyun@scu.edu.cn
  • Supported by:
    Youth Program of National Natural Science Foundation of China(81400501)

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Abstract:

The technology of tooth bonding is improved for many generations and is widely used in the field of oral defect repair. The dental adhesive technique can meet the conservative clinical treatment requirements, but the issue that the dentin-adhesive interface deteriorates over time remains. The structure of tea polyphenols contains multiple phenolic hydroxyl groups, which easily form hydrogen bonds with dentin collagen molecules, thereby improving the durability of the resin dentin adhesion repair. In recent years, the effects of the addition of epigallocatechin-3-gallate (EGCG), the main active substance in tea polyphenols, on the dentin bonding effect and the mechanism of action have become the research focus. In this paper, the role of EGCG in the dentin bonding process and the corresponding mechanism are reviewed.

Key words: tea polyphenols, epigallocatechin-3-gallate, dentin bonding system, bonding agent, matrix metalloproteinase

CLC Number: 

  • R783.1

TrendMD: 

Tab 1

Molecular mechanism of MMP degradation of dentin collagen"

亚类 分子机制
MMP-1、MMP-3、MMP-9 有研究[28]表明,人肝星状细胞高表达MMP-1后抑制Ⅰ型胶原蛋白表达的机制主要通过发挥其酶活性降解Ⅰ型胶原蛋白,而不影响Ⅰ型胶原基因水平的表达。
此外,研究证实激活蛋白1（activator protein-1,AP-1）在MMP-1、MMP-3和MMP-9的转录上调中起关键作用,MMP-1过表达导致Ⅰ型胶原纤维中心三螺旋内的特定位置开始裂解,一旦裂解,这些纤维被MMP-3和MMP-9进一步降解。
MMP-2 研究显示,MMP-2降解Ⅰ型胶原的表达涉及多个信号通路,包括环磷酸腺苷（cyclic adinosine monophosphate,cAMP）依赖蛋白激酶（protein kinaseA,PKA）、 AP-1、核因子κB（nuclear factor kappa-B,NF-κB）和丝裂原活化蛋白激酶（mitogen activated protein kinases,MAPK）家族等信号通路。Xie等[29]在研究中采用上述通路的抑制剂来观察通路抑制剂对激活的MMP-2在细胞外基质中的影响,结果显示6种抑制剂均在不同程度上降低MMP-2的表达或去除MMP-2的活性形式。
除了MMP-2可降解Ⅰ型胶原,Ⅰ型胶原也在MMP-2活化中起作用[30]。两者调控机制研究较多的是p38/细胞外调节蛋白激酶（extracellular regulated protein kinases,ERK）通路[31]。Koontongkaew等[32]的研究发现,Ⅰ型胶原可以通过ERK1/2、p38等通路活化MMP-2。
[1] Chen C, Niu LN, Xie H, et al. Bonding of universal adhesives to dentine: old wine in new bottles[J]. J Dent, 2015,43(5):525-536.
doi: 10.1016/j.jdent.2015.03.004 pmid: 25797702
[2] 赵信义, 刘晗, 施长溪. 牙本质的湿粘接[J]. 牙体牙髓牙周病学杂志, 2001,11(1):48-50.
Zhao XY, Liu H, Shi CX. The wet bonding of dentin[J]. Chin J Conserv Dent, 2001,11(1):48-50.
[3] Breschi L, Maravic T, Cunha SR, et al. Dentin bonding systems: from dentin collagen structure to bond pre- servation and clinical applications[J]. Dent Mater, 2018,34(1):78-96.
doi: 10.1016/j.dental.2017.11.005 pmid: 29179971
[4] Guo JM, Lei WL, Yang HY, et al. Dimethyl sulfoxide wet-bonding technique may improve the quality of dentin bonding[J]. J Adhes Dent, 2017: 229-237.
pmid: 11317397
[5] De Munck J, van den Steen PE, Mine A, et al. Inhibi-tion of enzymatic degradation of adhesive-dentin interfaces[J]. J Dent Res, 2009,88(12):1101-1106.
doi: 10.1177/0022034509346952 pmid: 19861692
[6] 古丽莎, 吴倩. 化学交联在牙本质粘接修复中的应用及展望[J]. 中华口腔医学研究杂志(电子版), 2019,13(3):129-135.
Gu LS, Wu Q. The chemical cross-linking applica-tions and perspectives in dentine adhesive[J]. Chin J Stomatol Res (Electron Ed), 2019,13(3):129-135.
[7] Kalaiselvam R, Ganesh A, Rajan M, et al. Evaluation of bioflavonoids on the immediate and delayed micro-tensile bond strength of self-etch and total-etch adhesive systems to sound dentin[J]. Indian J Dent Res, 2018,29(2):133-136.
doi: 10.4103/ijdr.IJDR_284_17 pmid: 29652002
[8] Singh P, Nagpal R, Singh UP. Effect of dentin bio-modifiers on the immediate and long-term bond strengths of a simplified etch and rinse adhesive to dentin[J]. Restor Dent Endod, 2017,42(3):188-199.
doi: 10.5395/rde.2017.42.3.188 pmid: 28808635
[9] Priyadarshini BM, Mitali K, Lu TB, et al. PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface[J]. Dent Mater, 2017,33(7):830-846.
doi: 10.1016/j.dental.2017.04.015 pmid: 28506608
[10] Albuquerque N, Neri JR, Lemos M, et al. Effect of polymeric microparticles loaded with catechin on the physicochemical properties of an adhesive system[J]. Oper Dent, 2019,44(4):E202-E211.
pmid: 30849016
[11] Yu HH, Zhang L, Xu S, et al. Effects of epigallocate-chin-3-gallate (EGCG) on the bond strength of fiber posts to sodium hypochlorite (NaOCl) treated in-traradicular dentin[J]. Sci Rep, 2017,7(1):4235.
pmid: 28652570
[12] Pheenithicharoenkul S, Panichuttra A. Epigalloca-techin-3-gallate increased the push out bond strength of an epoxy resin sealer to root dentin[J]. Dent Mater J, 2016,35(6):888-892.
doi: 10.4012/dmj.2016-137 pmid: 27680035
[13] Yu HH, Zhang L, Yu F, et al. Epigallocatechin-3-gallate and epigallocatechin-3-O-(3-O-methyl)-gallate enhance the bonding stability of an etch-and-rinse adhesive to dentin[J]. Materials (Basel), 2017,10(2):E183.
[14] Khamverdi Z, Rezaei-Soufi L, Rostamzadeh T. The effect of epigallocatechin gallate on the dentin bond durability of two self-etch adhesives[J]. J Dent (Shiraz), 2015,16(2):68-74.
[15] 贾智, 周游, 赵梦明. 口腔复合树脂粘接剂的研究进展[J]. 天津医科大学学报, 2017,23(2):182-184.
Jia Z, Zhou Y, Zhao MM. Research progress of oral composite resin adhesives[J]. J Tianjin Med Univ, 2017,23(2):182-184.
[16] Bedran-Russo AK, Pauli GF, Chen SN, et al. Dentin biomodification: strategies, renewable resources and clinical applications[J]. Dent Mater, 2014,30(1):62-76.
doi: 10.1016/j.dental.2013.10.012 pmid: 24309436
[17] Monteiro TMA, Basting RT, Turssi CP, et al. Influence of natural and synthetic metalloproteinase inhibitors on bonding durability of an etch-and-rinse adhesive to dentin[J]. Int J Adhes Adhes, 2013,47:83-88.
doi: 10.1016/j.ijadhadh.2013.09.020
[18] Castellan CS, Bedran-Russo AK, Antunes A, et al. Effect of dentin biomodification using naturally de-rived collagen cross-linkers: one-year bond strength study[J]. Int J Dent, 2013,2013:918010.
pmid: 24069032
[19] Zhang SC, Kern M. The role of host-derived dentinal matrix metalloproteinases in reducing dentin bonding of resin adhesives[J]. Int J Oral Sci, 2009,1(4):163-176.
doi: 10.4248/IJOS.09044 pmid: 20690420
[20] Hiraishi N, Sono R, Sofiqul I, et al. In vitro evalua-tion of plant-derived agents to preserve dentin collagen[J]. Dent Mater, 2013,29(10):1048-1054.
doi: 10.1016/j.dental.2013.07.015 pmid: 23942145
[21] Melok AL, Lee LH, Mohamed Yussof SA, et al. Green tea polyphenol epigallocatechin-3-gallate-stearate inhibits the growth of Streptococcus mutans: a pro-mising new approach in caries prevention[J]. Dent J (Basel), 2018,6(3):E38.
[22] Yu J, Yang HY, Li K, et al. Development of epigal-locatechin-3-gallate-encapsulated nanohydroxyapatite/mesoporous silica for therapeutic management of dentin surface[J]. ACS Appl Mater Interfaces, 2017,9(31):25796-25807.
doi: 10.1021/acsami.7b06597 pmid: 28703572
[23] Liu J, Lu Y, Liu J, et al. Influence of epigallocatechin-3-gallate in promoting proliferation and osteogenic differentiation of human periodontal ligament cells[J]. BMC Oral Health, 2019,19(1):73.
doi: 10.1186/s12903-019-0768-7 pmid: 31046751
[24] Mazzoni A, Breschi L, Carrilho M, et al. A review of the nature, role, and function of dentin non-collagenous proteins. Part Ⅱ: enzymes, serum proteins, and growth factors[J]. Endod Topics, 2009,21(1):19-40.
doi: 10.1111/etp.2012.21.issue-1
[25] 徐帅. 表没食子儿茶素没食子酸酯保护脱矿牙本质基质的相关作用研究[D]. 西安: 第四军医大学, 2014.
Xu S. Study on the protective effect of epigallocate-chin gallate on the demineralized dentin matrix[D]. Xi’an: The Fourth Military Medical University, 2014.
[26] 孙素, 肖玉鸿. 基质金属蛋白酶介导牙本质粘接界面的生物降解及其拮抗剂的研究进展[J]. 中华口腔医学研究杂志(电子版), 2015,9(4):333-336.
Sun S, Xiao YH. The progress on the biodegradation of resin-dentin adhesive interface mediated by the matrix metalloproteinases and its antagonists[J]. Chin J Stomatol Res (Electron Ed), 2015,9(4):333-336.
[27] 陈宇江, 刘宁, 李芳, 等. 提高牙本质粘接界面稳定性的研究进展[J]. 中华口腔医学杂志, 2013,48(2):119-122.
Chen YJ, Liu N, Li F, et al. Progress in improving the stability of dentin bonding interface[J]. Chin J Stomatol, 2013,48(2):119-122.
[28] 刘天会, 丛敏, 王萍, 等. MMP-1过表达抑制人肝星状细胞Ⅰ型胶原表达[J]. 肝脏, 2009,14(4):291-294.
Liu TH, Cong M, Wang P, et al. Overexpression of MMP-1 significantly degrades type Ⅰ collagen in human hepatic stellate cells[J]. Chin Hepatol, 2009,14(4):291-294.
[29] Xie J, Wang CL, Yang WB, et al. Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments[J]. J Tissue Eng Regen Med, 2018,12(1):e550-e565.
doi: 10.1002/term.2325 pmid: 27684403
[30] 田甜, 朱煌, 王洁, 等. MMP-2与Ⅰ型胶原关系的研究进展[J]. 现代生物医学进展, 2015,15(9):1775-1777, 1759.
Tian T, Zhu H, Wang J, et al. MMP-2 and collagen type Ⅰ[J]. Prog Mod Biomed, 2015,15(9):1775-1777, 1759.
[31] 汪婷, 孔祥权, 王伟华. Ac-SDKP对Ang Ⅱ诱导的大鼠血管外膜成纤维细胞胶原合成的调节作用[J]. 中国应用生理学杂志, 2013,29(2):179-181, 192.
Wang T, Kong XQ, Wang WH. Effects of Ac-SDKP on angiotensin Ⅱ-induced collagen synjournal in vascular adventitial fibroblasts[J]. Chin J Appl Physiol, 2013,29(2):179-181, 192.
[32] Koontongkaew S, Amornphimoltham P, Monthan-pisut P, et al. Fibroblasts and extracellular matrix differently modulate MMP activation by primary and metastatic head and neck cancer cells[J]. Med Oncol, 2012,29(2):690-703.
doi: 10.1007/s12032-011-9871-6 pmid: 21380786
[33] Fialho MPN, Hass V, Nogueira RP, et al. Effect of epigallocatechin-3- gallate solutions on bond dura-bility at the adhesive interface in caries-affected dentin[J]. J Mech Behav Biomed Mater, 2019,91:398-405.
pmid: 30669058
[34] Fonseca BM, Barcellos DC, Silva TMD, et al. Me-chanical-physicochemical properties and biocom-patibility of catechin-incorporated adhesive resins[J]. J Appl Oral Sci, 2019,27:e20180111.
doi: 10.1590/1678-7757-2018-0111 pmid: 30624464
[35] Gerhardt KMF, Oliveira CAR, França FMG, et al. Effect of epigallocatechin gallate, green tea extract and chlorhexidine application on long-term bond strength of self-etch adhesive to dentin[J]. Int J Adhes Adhes, 2016,71:23-27.
doi: 10.1016/j.ijadhadh.2016.08.005
[36] Chang CW, Hsieh YH, Yang WE, et al. Epigallocate-chingallate inhibits migration of human uveal me-lanoma cells via downregulation of matrix metallo-proteinase-2 activity and ERK1/2 pathway[J]. Biomed Res Int, 2014,2014:141582.
doi: 10.1155/2014/141582 pmid: 25184134
[37] Li YF, Wang H, Fan Y, et al. Epigallocatechin-3-gallate inhibits matrix metalloproteinase-9 and mo-nocyte chemotactic protein-1 expression through the 67-κDa laminin receptor and the TLR4/MAPK/NF-κB signalling pathway in lipopolysaccharide-induced macrophages[J]. Cell Physiol Biochem, 2017,43(3):926-936.
pmid: 28957799
[38] Ho HC, Huang CC, Lu YT, et al. Epigallocatechin-3-gallate inhibits migration of human nasopharyngeal carcinoma cells by repressing MMP-2 expression[J]. J Cell Physiol, 2019,234(11):20915-20924.
doi: 10.1002/jcp.28696 pmid: 31012106
[39] Sarkar J, Chakraborti T, Chowdhury A, et al. Protective role of epigallocatechin-3-gallate in NADPH oxi-dase-MMP2-Spm-Cer-S1P signalling axis mediated ET-1 induced pulmonary artery smooth muscle cell proliferation[J]. J Cell Commun Signal, 2019,13(4):473-489.
doi: 10.1007/s12079-018-00501-7 pmid: 30661173
[40] Madhan B, Subramanian V, Rao JR, et al. Stabilization of collagen using plant polyphenol: role of catechin[J]. Int J Biol Macromol, 2005,37(1/2):47-53.
doi: 10.1016/j.ijbiomac.2005.08.005
[41] Xu YT, Huang CC, Li L, et al. In vitro enzymatic degradation of a biological tissue fixed by alginate dialdehyde[J]. Carbohydr Polym, 2013,95(1):148-154.
pmid: 23618251
[42] Kasraei S, Mojtahedi M, Goodarzi MT, et al. The effect of dentin pre-treatment with activated ribo-flavin on the bond strength of a two-step self-etch adhesive system[J]. Dent Med Probl, 2019,56(2):143-148.
doi: 10.17219/dmp/105408 pmid: 31274252
[43] Souza MY, Jurema ALB, Caneppele TMF, et al. Six-month performance of restorations produced with the ethanol-wet-bonding technique: a randomized trial[J]. Braz Oral Res, 2019,33:e052.
pmid: 31269116
[44] Ochiai Y, Inoue G, Nikaido T, et al. Evaluation of experimental calcium-containing primer in adhesive system on micro-tensile bond strength and acid resistance[J]. Dent Mater J, 2019,38(4):565-572.
doi: 10.4012/dmj.2018-266 pmid: 31231106
[45] Rayar S, Sadasiva K, Singh P, et al. Effect of 2% chlorhexidine on resin bond strength and mode of failure using two different adhesives on dentin: an in vitro study[J]. J Pharm Bioallied Sci, 2019,11(Suppl 2):S325-S330.
doi: 10.4103/JPBS.JPBS_23_19 pmid: 31198363
[46] Yang HY, Guo JM, Deng DL, et al. Effect of adjun-ctive application of epigallocatechin-3-gallate and ethanol-wet bonding on adhesive-dentin bonds[J]. J Dent, 2016,44:44-49.
doi: 10.1016/j.jdent.2015.12.001 pmid: 26655074
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .