Int J Stomatol

Inter J Stomatol ›› 2014, Vol. 41 ›› Issue (6): 631-634.doi: 10.7518/gjkq.2014.06.003

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Matrix metalloproteinase 2 expression in implant-bone interface remodeling influenced by submerged and nonsubmerged implant denture

Yuan Lin, Chen Xie, Cheng Feng, Yang Zhengyi, Pan Guangsi, Wang Han, Sun Jin, Cao Yina   

  1. Dept. of Stomatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China
  • Online:2014-11-01 Published:2014-11-01

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Abstract:

Objective This study was designed to investigate the matrix metalloproteinase 2(MMP2) expression in implant-bone interface remodeling after loading the submerged and nonsubmerged implant dentures. Methods Eight adult beagle dogs were used to construct the animal model. Submerged and nonsubmerged implants were implanted into the bilateral mandible. Fixed metal full crown was used to load the submerged and nonsubmerged implant denture. The beagle dogs were sacrificed after loading. Immunohistochemistry was used to observe the dynamic MMP2 expression in the implant-bone interface. Results MMP2 expression in the implant-bone interface of the experimental group was significantly enhanced compared with that of the control group after loading of implant denture. MMP2 expression in the interface was observed 2 weeks after implant denture loading, but no statistically significant difference was found between the experimental and control groups. MMP2 expression in the experimental group was significantly higher than that in the control group at 4 and 8 weeks after loading, and the peak was reached at 4 weeks. Then, the MMP2 expression in the experimental group declined to the level of the control group after 12 weeks. No obvious difference was observed in the MMP2 expression in the implant-bone interface between the submerged and nonsubmerged implant denture. Conclusion The mechanical stress that was transferred from the implant to the bone tissue after loading of the submerged and nonsubmerged implant denture can stimulate MMP2 expression in the implant-bone interface, promoting interface remodeling. Furthermore, no distinct difference was observed in the implant-bone interface remodeling after the loading of submerged and nonsubmerged implant denture.

Key words: submerged, nonsubmerged, implant-bone interface, loading, remodeling, matrix metalloproteinase 2


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