Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (6): 782-785.doi: 10.7518/gjkq.2013.06.022

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Role of micro ribonucleicacid in bone remodeling

Wang Yan, Huang Hui   

  1. Dept. of Prosthodontics, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Received:2013-02-16 Revised:2013-06-15 Online:2013-11-01 Published:2013-11-01

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Abstract:

Micro ribonucleicacid(miRNA) is key post-transcriptional regulator of gene expression, which widely exists in all kinds of plants and animals and microorganisms and participates in the biology growth, cell differentiation, apoptosis and so many kinds of life processes. Hence, the formation, differentiation, proliferation and remodeling of bone are closely associated with miRNA. This review will highlight our current understanding of miRNA and mechanisms of action in bone remodeling. An in-depth understanding of the roles of the regulatory miRNA in bone remodeling will be crucial for the development of new therapeutics, which aim at treating bone loss and facilitating fracture repair. Meanwhile, this will raise a new sight of facilitating osseointegration and the success of implants.

Key words: micro ribonucleicacid, bone, bone remodeling

CLC Number: 

  • Q 786

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