Int J Stomatol ›› 2022, Vol. 49 ›› Issue (4): 476-482.doi: 10.7518/gjkq.2022067

• Reviews • Previous Articles     Next Articles

Research progress on the development of mesoporous calcium silicate nanoparticles in endodontics and repairing maxillofacial bone defects

Zhang Xidan(),Sun Jiyu,Fu Xinliang,Gan Xueqi.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-10-02 Revised:2022-03-08 Online:2022-07-01 Published:2022-06-28
  • Contact: Xueqi. Gan;
  • Supported by:
    National Natural Science Foundation of China(81870802)


Mesoporous calcium silicate nanoparticles (MCSNs), a novel bioactive material with a nanoscale size and an ordered mesoporous channel structure, possess excellent biocompatibility, bioactivity, antibacterial properties, and drug delivery characteristics. Besides, they can be modified by metal elements and improve the properties of biocomposites. Therefore, the development of MCSNs is currently a research focus in stomatology. MCSNs have antibacterial activity against a range of common oral pathogens. Moreover, they can cover the root canal wall, infiltrate the dentinal tubules, and induce cementum tissue regeneration; therefore, they have a potential in the endodontics field. Furthermore, MCSN scaffold showed excellent ability in osteogenesis and modification and thus could be potentially applied in oral and maxillofacial surgeries. This article reviews the biological properties and research progress of MCSNs in endodontics and their application in the repair of maxillofacial bone defects and provides preliminary experimental basis for further research on MCSNs.

Key words: mesoporous calcium-silicate nanoparticle, biocompatibility, bioactivity, antibacterial property, drug delivery property, biological property, endodontics, maxillofacial bone defect

CLC Number: 

  • R 318.08

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