Int J Stomatol

Int J Stomatol ›› 2024, Vol. 51 ›› Issue (1): 107-115.doi: 10.7518/gjkq.2024004

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Applications and research progress of biodegradable magnesium-based materials in craniomaxillofacial surgery

Chang Xinnan(),Liu Lei()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Trauma and Orthopedic Wards, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2023-03-02 Revised:2023-08-01 Online:2024-01-01 Published:2024-01-10
  • Contact: Lei Liu E-mail:cxn990407@163.com;drliulei@163.com
  • Supported by:
    Applied Basic Research Project of Sichuan Provincial Science and Technology Program(2020YJ0278)

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Abstract:

As a new generation of bone-implant materials, biodegradable magnesium-based materials show potential application in craniomaxillofacial surgery. Compared with traditional bone-implant materials, magnesium-based materials have excellent degradability, biocompatibility, mechanical properties, and osteogenic-promoting ability. The degradation of Mg implants leads to the production of magnesium ions, which have antiapoptosis and anti-inflammatory functions. Magnesium ions can also promote the healing of fractures and bone defects. Many studies have applied biodegradable magnesium-based materials to the internal fixation of craniomaxillofacial fractures, bone-substitute applications, guided bone regeneration, drug delivery, and implant surface coating. Results reveal that this kind of materials can provide stable support for bone healing and play a suitable role in osteogenic promoting. Magnesium-based materials also demonstrate potential in other fields, such as dental-tissue engineering and promotion of soft-tissue healing. All these findings indicate the importance of magnesium-based materials.

Key words: biodegradable magnesium-based material, internal fixation, guided bone regeneration, bone substitutes, drug delivery system, magnesium coating

CLC Number: 

  • R782.2

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