Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (6): 739-746.doi: 10.7518/gjkq.2023081

• Reviews • Previous Articles    

Modification of silk fibroin-based hydrogels and their applications for bone tissue engineering

Chen Runzhi1(),Zhang Wentao2,Chen Feng3,Yang Fan2()   

  1. 1.School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, China
    2.Dept. of Stomatology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital of Hangzhou Medical College), Hangzhou 310014, China
    3.School of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2023-01-01 Revised:2023-06-06 Online:2023-11-01 Published:2023-10-24
  • Contact: Fan Yang E-mail:runzhi_chen@163.com;yangfan@hmc.edu.cn
  • Supported by:
    Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2021KY068)

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Abstract:

The repair and reconstruction of large bone defects require a thorough understanding of the physicochemical and biological properties of bone tissue, as well as bionic strategies to prepare suitable bone tissue engineering scaffolds. Silk protein is a natural polymer material with unique biological properties. Hydrogels prepared with silk protein as their main component are also promising scaffold materials. Certain properties of the hydrogel need to be modified to meet the requirements of an ideal scaffold for bone tissue engineering. Therefore, this paper reviews the modification methods to silk fibroin hydrogel when applied to bone tissue engineering in terms of enhancing mechanical properties, increasing biological inductivity, and regulating biodegradability.

Key words: silk fibroin, hydrogels, bone tissue engineering, modification

CLC Number: 

  • R 783.1

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