Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 261-266.doi: 10.7518/gjkq.2018.03.003

• Stem Cell • Previous Articles     Next Articles

Epigenetic regulation in dental pulp stem cells

Zhang Xin, Wang Chenglin, Yang Jing, Ye Ling   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-08-07 Revised:2017-12-15 Published:2018-05-08
  • Supported by:
    This study supported by International Science & Technology Cooperation Program of China (2014DFA31990).

Abstract: Dental pulp stem cells (DPSCs) are adult stem cells with self-renewal ability and multiple differentiation potential. These cells play an important role in dental pulp repair, tooth regeneration, and bone tissue engineering. Epigenetics refers to heritable changes in gene expression without alteration of DNA sequence; these changes include DNA methylation, histone modification, and non-coding RNA regulation. Epigenetic modification plays an important role in regulation of DPSCs by influencing gene transcription. Thus, this study aims to elaborate epigenetic regulations of DPSCs.

Key words: epigenetic, dental pulp stem cell, DNA methylation, histone modification, non-coding RNA

CLC Number: 

  • Q756

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