Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 267-271.doi: 10.7518/gjkq.2018.03.004

• Stem Cell • Previous Articles     Next Articles

Regulate process of long non-coding RNA in multi-differentiation of mesenchymal stem cells

Ge Yihong1, Fang Fuchun1,2, Wu Buling1,2   

  1. 1. Dept. of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;
    2. School of Stomatology, Southern Medical University, Guangzhou 510515, China
  • Received:2017-11-03 Revised:2018-01-26 Published:2018-05-08
  • Supported by:
    This study was supported by National Natural Science Fundation of China (81600882) and Medical Scientific Research Foundation of Guangdong Province (A2016190).

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Abstract: Mesenchymal stem cells (MSCs) derived from mesoderm exhibit self-renewal and multiple differentiation potentials. MSCs are considerably useful in tissue repair and cell development, with the ability to differentiate into osteoblasts, chondrocytes, adipocytes, myoblasts, neurocytes and other cells. Long noncoding RNAs (lncRNAs) are differentially expressed in the differentiation of MSCs. This result indicated that lncRNAs are crucial in regulation during differentiation. To date, most reports mainly focused on microarray and bioinformatics analysis of lncRNAs. The function and regulatory mechanism of lncRNAs on the differentiation of MSCs still remain unclear. However, with the development in new research technologies, the regulatory mechanism of lncRNA in the differentiation of MSCs will be intensively elucidated.

Key words: mesenchymal stem cell, long noncoding RNA, multi-differentiation

CLC Number: 

  • Q254

TrendMD: 
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