Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (6): 690-695.doi: 10.7518/gjkq.2021106

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Research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair

Shi Peilei(),Yu Chenhao,Xie Xudong,Wu Yafei,Wang Jun()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-24 Revised:2021-07-16 Online:2021-11-01 Published:2021-10-28
  • Contact: Jun Wang E-mail:shipeilei0222@outlook.com;junwang@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82071127);National Natural Science Foundation of China(81700980);Sichuan Province Science and Technology Support Program(2019YJ0097)

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Abstract:

Periodontitis is a chronic infectious disease characterized by the destruction of periodontal tissue and is the most common cause of tooth loss among adults. The periodontium is a complex structure composed of soft and hard tissues; hence, the regeneration of its tissues is a challenging task. Self-renewal, multipotency, and accessibility make dental-derived mesenchymal stem cells an attractive source for periodontal tissue regeneration. With the development of cell-sheet engineering, biomaterial scaffolds, and 3D printing, dental-derived mesenchymal stem cells show great potential as seed cells in repairing periodontal tissue defects. This paper reviews the research progress on the application of dental-derived mesenchymal stem cells in periodontal defect repair.

Key words: dental-derived mesenchymal stem cell, periodontal tissue repair, tissue engineering, periodontitis

CLC Number: 

  • Q254

TrendMD: 
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