Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 263-271.doi: 10.7518/gjkq.2022029

• Stem Cells and Regenerative Medicine • Previous Articles     Next Articles

Advances in research on noncoding RNA during the osteogenic differentiation of dental follicle stem cells

Hong Yaya1(),Chen Xuepeng1,Si Misi2()   

  1. 1.Dept. of Orthodontics, The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
    2.Dept. of Implantology, The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China
  • Received:2021-09-29 Revised:2021-12-09 Online:2022-05-01 Published:2022-05-09
  • Contact: Misi Si;
  • Supported by:
    Natural Science Foundation of Zhejiang Province(LY18H140001)


Alveolar bone-defect regeneration has long been a challenge in the field of dentistry. The rising technology of periodontal tissue engineering provides a new strategy to solve it, and ideal seed cells are key elements of this technology. Dental follicle stem cells (DFSCs), as promising seed cells, have the potential of osteogenic differentiation, which are also easily accessible for cell culture and preservation. The osteogenic differentiation of DFSCs involves complex gene regulation. Noncoding RNA (ncRNA), as a functional RNA that is transcribed from DNA but does not encode protein, can reportedly regulate the osteogenic differentiation of stem cells at the epigenetic, transcription, and post-transcription le-vels. Exploring the role and mechanism of ncRNA in the regulatory network of DFSCs’ osteogenic differentiation can provide novel therapeutic strategies for tissue regeneration. This review summarizes the advances in research on ncRNA during the osteogenic differentiation of DFSCs, including microRNA, long noncoding RNA, and circular RNA.

Key words: dental follicle stem cell, noncoding RNA, micro RNA, long noncoding RNA, circular RNA, osteogenic differentiation

CLC Number: 

  • Q 254


Tab 1

ncRNAs involved in the regulation on osteogenic differentiation of DFSCs"

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