Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (5): 512-519.doi: 10.7518/gjkq.2021090

• Cleft Lip and Palate • Previous Articles     Next Articles

Application of twin model in etiology of cleft lip with or without cleft palate

Ma Xiaofang1(),Huang Yongqing2,Shi Bing3,Ma Jian2()   

  1. 1. School of Stomatology, Ningxia Medical University, Yinchuan 750003, China
    2. Dept. of Oral and Maxillofacial Surgery, General Hospital of Ningxia Medical University, Yinchuan 750004, China
    3. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-23 Revised:2021-06-15 Online:2021-09-01 Published:2021-09-10
  • Contact: Jian Ma E-mail:1725365869@qq.com;majianhs310@163.com
  • Supported by:
    National Natural Science Foundation of China(81600853);Key Research and Development Project of Ningxia Hui Autonomous Region(2021BEG2043);School Level Research Project of Ningxia Medical University(XT2015018)

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Abstract:

Cleft lip with or without cleft palate (CL/P) is one of the most common congenital cranio/maxillofacial deformities. The cause of the disease is complicated, which is considered to be a genetic disease mainly due to genetic and environmental factors. Twins, who share similar genetic information and environmental factors, are considered ideal models for studying the aetiology of inherited diseases. By reviewing the literature, this paper reviews the classification and identification of twins, the advantages and uses of the twin model and the application and progress of the twin model in the screening of susceptibility genes of CL/P to provide a new idea for further exploration of the causes of CL/P.

Key words: cleft lip with or without cleft palate, twins, monozygotic twin, epigenetics

CLC Number: 

  • R34

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