Int J Stomatol

Inter J Stomatol ›› 2013, Vol. 40 ›› Issue (2): 144-147.doi: 10.7518/gjkq.2013.02.002

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Association between genetic polymorphism of methylenetetrahydrofolate dehydrogenase 1, mehionine synthase and non-syndromic cleft lip with or without cleft palate in Shanxi, China

Li Ruifang,  Ma Xuefang, Nan Xinrong   

  1. 1. Dept. of Oral and Maxillofaxial Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030001, China; 2. Dept. of Oral and Maxillofaxial Surgery, The First People’s Hospital of Jinzhong, Jinzhong 030600, China
  • Received:2012-04-19 Revised:2012-11-01 Online:2013-03-01 Published:2013-03-01
  • Contact: Nan Xinrong, Tel： 13903434186

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Abstract:

Objective To investigate the association between genetic polymorphism of methylenetetrahydrofolate dehydrogenase（MTHFD）1 and mehionine synthas（MTR） and non-syndromic cleft lip with or without cleft palate （NSCL/P）. Methods Collected the mucosa of the experimental group consisted of 187 NSCL/P patients and control group consisted of 157 normal mucosa. DNA was extracted and identified the genotypes of the samples: MTHFD1（rs2236225） and MTR（rs1805087）. Compared with two groups of genotype and allele frequency, analysis of genotype distribution frequency and relationship between two genes’ interaction with NSCL/P. Results There was no statistical difference in genotype and gene frequencies between case group and control group of MTR and MTHFD1 （P>0.05）. The odds ratio of genotype AG, GG of MTR were 0.308, 0.501. The odds ratio of genotype GA, AA of MTHFD1 were 0.812, 0.196. According to AA-GG, the odds ratio of genotype between AG-AA, GG-GA and GGAA were 2.078, 4.508 and 6.497. Conclusion None association between genetic polymorphism of MTHFD1, MTR and NSCL/P, but the interaction of MTHFD1 and MTR is the risk factor of the NSCL/P.

Key words: non-syndromic cleft lip with or without cleft palate, mehionine synthase, methylenetetrahydrofolate dehydrogenase 1, single nucleotide polymorphism


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