Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (6): 631-634.doi: 10.7518/gjkq.2015.06.004

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Matrix metalloproteinase 1, 3 and 9 gene polymorphism and the risk of oral squamous cell carcinomas among Han Chinese in Yunnan

Li Lanjiang1, Xu Bingying1, Yang Chunyan2, Zhao Chuan3, Tian Xin2.   

  1. 1. Dept. of Forensics Biological Evidence and Criminal Investigation Technology, Institute of Forensic Medicine, Kunming Medical University, Kunming 650500, China; 2. Dept. of Oral Histopathological, Kunming Medical University, Kunming 650500, China; 3. Dept. of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming 650500, China
  • Received:2015-01-02 Revised:2015-07-28 Online:2015-11-01 Published:2015-11-01

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Abstract:

Objective To explore matrix metalloproteinase(MMP)1, MMP3, and MMP9 gene polymorphisms are studied to determine the risk of developing oral squamous cell carcinoma(OSCC) among Han Chinesein Yunnan. Methods The polymerase chain reaction-restriction fragment length polymorphism method is used to detect 3 loci single nucleotide polymorphisms(SNPs) of the MMP1 promoter(1607 1G/2G), MMP3 promoter(1171 5A/6A), and MMP9 promoter(1562C/T) among 54 patients diagnosed with OSCC(OSCC group) and 55 healthy subjects(control group). Results The distribution of the 3 loci of the MMP1 promoter(1607 1G/2G, 2G/2G, 1G/2G) genotype frequencies among the control group were 11.11%, 37.04%, and 51.85%, respectively, and 5.66%, 43.40%, and 50.94%, respectively, among the OSCC group. The distributions of 5A/5A, 6A/6A, and 5A/6A of the MMP3 promoter(1171 5A/6A) were 0, 75.93%, and 24.07% among the control group, respectively, and 8.33%, 72.92%, and 18.75% among the OSCC group, respectively. The distributions of CC, TT, and CT of the MMP9 promoter(1562C/T) were 100%, 0, and 0 among the control group, respectively, and 100%, 0, and 0 among the OSCC group, respectively. The SNPs of MMP1, MMP3, MMP9, and the risk of OSCC have no significant correlation(P>0.05). The 3 sites with high-, medium-, and low-risk differentiation of OSCC have no significant correlation(P>0.05). Conclusion The existence of 3 loci SNPs of the MMP1 promoter(1607 1G/2G), MMP3 promoter(1171 5A/6A), and MMP9 promoter(1562C/T) among Han Chinese in Yunnan has an insignificant correlation to the risk of developing OSCC.

Key words: oral squamous cell carcinomas, matrix metalloproteinase, single nucleotide polymorphism

CLC Number: 

  • R 782

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