Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (2): 225-228.doi: 10.3969/j.issn.1673-5749.2011.02.027

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Expression and effects of membrane type-1-matrix metalloprotease on bone metabolism, oral development and diseases

ZHANG Xin, GU Zhi-yuan.   

  1. Dept. of Implantology, The Affiliated Stomatological Hospital of Medical College, Zhejiang University, Hangzhou 310006, China
  • Received:2010-02-10 Revised:2010-09-03 Online:2011-03-20 Published:2011-03-20

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Abstract:

Membrane type（MT）-1 -matrix metalloproteinase（MMP） is a member of MMP family. It has been found in osteoclasts and osteoblasts. It plays an important role on the bone metabolism. And mt-1-mmp-deficient mice develop serious disorder of bone metabolism. Various kinds of oral disease have connection with bone metabolism and MT-1-MMP. This article reviewed the structure and function of MT-1-MMP, and effects on bone metabolism, oral development and diseases.

Key words: membrane type-1-matrix metalloproteinase, osteoclast, osteoblast, oral development and diseases


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