Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (3): 316-319.doi: 10.7518/gjkq.2019021

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Research progress on osteoprotegerin in oral science

Xin Gao,Rongsheng Zeng()   

  1. Dept. of Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2018-06-06 Revised:2018-12-13 Online:2019-05-01 Published:2019-06-05
  • Contact: Rongsheng Zeng E-mail:rszeng@yahoo.ca
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81070818)

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Abstract:

Known as a new member of the tumour necrosis factor receptor superfamily, osteoprotegerin (OPG) inhibits osteoclastogenesis and osteoclast activation through the receptor-activator of nuclear factor-κB ligand (RANKL)/receptor-activator of nuclear factor-κB (RANK)/OPG signal pathway. Additionally, osteoclasts are directly involved in the regulation of bone metabolism and play a major role in alveolar bone reconstruction and root resorption. This review focused on the implications of osteoprotegerin during orthodontic tooth movement, periodontitis, osteointegration, tooth eruption and other oral aspects.

Key words: osteoprotegerin, osteoclast, alveolar bone reconstruction, root resorption, osteointegration

CLC Number: 

  • Q257

TrendMD: 
[1] Nimeri G, Kau CH, Abou-Kheir NS , et al. Accele-ration of tooth movement during orthodontic treat-ment—a frontier in orthodontics[J]. Prog Orthod, 2013,14:42.
doi: 10.1186/2196-1042-14-42 pmid: 24326040
[2] Barbieri G, Solano P, Alarcón JA , et al. Biochemical markers of bone metabolism in gingival crevicular fluid during early orthodontic tooth movement[J]. Angle Orthod, 2013,83(1):63-69.
doi: 10.2319/022812-168.1 pmid: 22716279
[3] Flórez-Moreno GA, Isaza-Guzmán DM , Tobón-Ar-royave SI. Time-related changes in salivary levels of the osteotropic factors sRANKL and OPG through orthodontic tooth movement[J]. Am J Orthod Dento-facial Orthop, 2013,143(1):92-100.
doi: 10.1016/j.ajodo.2012.08.026 pmid: 23273364
[4] 潘克清, 张朋梅, 邓婧 , 等. OPG/RANK/RANKL在牙周炎联合血管钙化大鼠牙髓组织中的表达及意义[J]. 上海口腔医学, 2016,25(4):391-395.
Pan KQ, Zhang PM, Deng J , et al. Expression of OPG/RANK/RANKL in the rat dental pulp tissue of periodontitis combined with vascular calcification and its clinical significance[J]. Shanghai J Stomatol, 2016,25(4):391-395.
[5] Fernández-González FJ, López-Caballo JL, Cañigral A , et al. Osteoprotegerin and zoledronate bone effects during orthodontic tooth movement[J]. Orthod Craniofac Res, 2016,19(1):54-64.
doi: 10.1111/ocr.12115 pmid: 26515913
[6] Zheng Y, Chen M, He L , et al. Mesenchymal dental pulp cells attenuate dentin resorption in homeostasis[J]. J Dent Res, 2015,94(6):821-827.
doi: 10.1177/0022034515575347 pmid: 4485326
[7] Barbato L, Francioni E, Bianchi M , et al. Periodon-titis and bone metabolism[J]. Clin Cases Miner Bone Metab, 2015,12(2):174-177.
[8] Tabari ZA, Azadmehr A, Tabrizi MA , et al. Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health[J]. J Periodontal Implant Sci, 2013,43(5):227-232.
doi: 10.5051/jpis.2013.43.5.227 pmid: 24236245
[9] Ozçaka O, Nalbantsoy A, Köse T , et al. Plasma os-teoprotegerin levels are decreased in smoker chronic periodontitis patients[J]. Aust Dent J, 2010,55(4):405-410.
doi: 10.1111/j.1834-7819.2010.01261.x pmid: 21133939
[10] Belibasakis GN, Bostanci N . The RANKL-OPG system in clinical periodontology[J]. J Clin Perio-dontol, 2012,39(3):239-248.
doi: 10.1111/j.1600-051X.2011.01810.x pmid: 22092994
[11] Sojod B, Chateau D, Mueller CG , et al. RANK/RANKL/OPG signalization implication in periodontitis: new evidence from a RANK transgenic mouse model[J]. Front Physiol, 2017,8:338.
doi: 10.3389/fphys.2017.00338 pmid: 5442248
[12] 韩劼, 陈智滨, 李玮 , 等. 早期愈合阶段牙种植体周沟液骨代谢相关因子的检测和种植体稳定性共振频率分析[J]. 北京大学学报(医学版), 2015,47(1):37-41.
doi: 10.3969/j.issn.1671-167X.2015.01.007
Han J, Chen ZB, Li W , et al. Determination of bone metabolic marker levels in perio-implant crevicular fluid and analysis of dental implants stability by resonance frequency in the early stage of healing[J]. J Peking Univ (Health Sci), 2015,47(1):37-41.
doi: 10.3969/j.issn.1671-167X.2015.01.007
[13] Prati AJ, Casati MZ, Ribeiro FV , et al. Release of bone markers in immediately loaded and nonloaded dental implants: a randomized clinical trial[J]. J Dent Res, 2013,92(12 Suppl):161S-167S.
doi: 10.1177/0022034513504951
[14] Liu Y, Hu J, Liu B , et al. The effect of osteoprote-gerin on implant osseointegration in ovariectomized rats[J]. Arch Med Sci, 2017,13(2):489-495.
[15] Kapasa ER, Giannoudis PV, Jia X , et al. The effect of RANKL/OPG balance on reducing implant com-plications[J]. J Funct Biomater, 2017,8(4). doi: 10. 3390/jfb8040042.
[16] Bradaschia-Correa V, Moreira MM, Arana-Chavez VE . Reduced RANKL expression impedes osteoclast activation and tooth eruption in alendronate-treated rats[J]. Cell Tissue Res, 2013,353(1):79-86.
doi: 10.1007/s00441-013-1623-9
[17] Dorotheou D, Gkantidis N, Karamolegkou M , et al. Tooth eruption: altered gene expression in the dental follicle of patients with cleidocranial dysplasia[J]. Orthod Craniofac Res, 2013,16(1):20-27.
doi: 10.1111/ocr.2013.16.issue-1
[18] Sun H, Li Q, Zhang Y , et al. Regulation of OPG and RANKL expressed by human dental follicle cells in osteoclastogenesis[J]. Cell Tissue Res, 2015,362(2):399-405.
doi: 10.1007/s00441-015-2214-8
[19] de Matos FR, de Moraes M, das Neves Silva EB , et al. Immunohistochemical detection of receptor ac-tivator nuclear κB ligand and osteoprotegerin in odontogenic cysts and tumors[J]. J Oral Maxillofac Surg, 2013,71(11):1886-1892.
doi: 10.1016/j.joms.2013.05.023
[20] Li B, Zhang Y, Wang Q , et al. Periodontal ligament stem cells modulate root resorption of human primary teeth via Runx2 regulating RANKL/OPG system[J]. Stem Cells Dev, 2014,23(20):2524-2534.
doi: 10.1089/scd.2014.0127
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
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[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .