Int J Stomatol

Inter J Stomatol ›› 2011, Vol. 38 ›› Issue (5): 574-577.doi: 10.3969/j.issn.1673-5749.2011.05.021

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Research progress on matrix metalloproteinase activity regulated by high glucose and the relationship with dental caries

Liu Jia, Ling Junqi.   

  1. Dept. of Conservative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510055, China
  • Received:2009-11-11 Revised:2011-05-25 Online:2011-09-20 Published:2011-09-20

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Abstract:

Caries is a process of degradation of dentin matrix by various proteolytic enzymes from bacteria and human host after dentin demineralized. Matrix metalloproteinase（MMP）, as the main endogenous enzymes, play important roles in caries development. The research progresses on MMP activity regulated by high glucose put a new direction for caries development in diabetics.

Key words: caries, matrix metalloproteinase, dentin


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