Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 332-336.doi: 10.7518/gjkq.2022030

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Classification and treatment of dentin dysplasia type Ⅰ

Lei Bin1(),Chen Ke2()   

  1. 1.School of Stomatology, Jinan University, Guangzhou 510000, China
    2.Dept. of Pediatric Dentistry, Haizhu Square, Stomatological Hospital of Southern Medical University, Guangzhou 510000, China
  • Received:2021-07-21 Revised:2021-11-06 Online:2022-05-01 Published:2022-05-09
  • Contact: Ke Chen E-mail:435186977@qq.com;dentchenke@sohu.com
  • Supported by:
    High-level Talents Project of Stomatological Hospital, Southern Medical University(PY2018022)

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Abstract:

Dentin dysplasia type Ⅰ (DD-Ⅰ) is a rare genetic disorder of dentine formation that affects all deciduous and permanent teeth. In this disease, the tooth crown’s appearance, color, and lustre are normal; tooth loosening is obvious; and spontaneous tooth alveolar abscess or cyst may be present. Imaging examinations show that the pulp cavity disappeared or the residual pulp has a “crescent shape” and the root is short and blunt or the root is absent. The pathogenesis of DD-Ⅰ has been studied by most scholars, and its clinical treatment is often challenging. In this paper, the clinical classification and manifestations, pathogenic genes, histological characteristics, and treatment of DD-Ⅰ in recent years are reviewed to provide guidance for the clinical diagnosis and treatment of this disease.

Key words: dentine dysplasia type Ⅰ, classification, pathogenesis, pathogenic gene, treatment

CLC Number: 

  • R 781.2

TrendMD: 

Fig 1

Sub-classification of DD Type Ⅰ"

Tab 1

Pathogenic genes of hereditary dentin disorders"

疾病类型基因位置致病基因
DGI-Ⅰ17q21.33COL1A1
7q21.3COL1A2
DGI-Ⅱ4q22.1DSPP
DGI-Ⅲ4q22.1DSPP
DD-Ⅰ6q27SMOC2
18q21.33VPS4B
3p26.1SSUH2
DD-Ⅱ4q22.1DSPP
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