Int J Stomatol ›› 2023, Vol. 50 ›› Issue (5): 618-622.doi: 10.7518/gjkq.2023056

• Reviews • Previous Articles    

Research progress on oral-craniomaxillofacial features and treatment of Down syndrome

Liu Ting(),Wu Xiuping.()   

  1. Key Laboratory of Oral Diseases Prevention and New Materials in Shanxi Province, Dept. of Orthodontics, Hospital of Stomatology, School of Stomatology, Shanxi Medical University, Taiyuan 030000, China
  • Received:2022-11-24 Revised:2023-05-10 Online:2023-09-01 Published:2023-09-01
  • Contact: Xiuping. Wu E-mail:1632668924@qq.com;77wxp@163.com
  • Supported by:
    Key Project of Science and Technology Research (Social Development) of Shanxi Province(201803D31065);Scientific Research Grant for Returned Overseas Chinese Students of Shanxi Province(HGKY-2019-055)

Abstract:

Down syndrome, also known as Trisomy 21, is a chromosomal abnormality associated with mental retardation or developmental delay, and may affect patient growth and their craniomaxillofacial growth and development. The stomatognathic system consists of a variety of complex anatomical and tissue structures that allow humans to perform functions such as articulation, mastication, and swallowing. The jaws, teeth, as well as muscles are important components of this system, in which changes in either structure can affect the functional exercise associated with it, thus affecting the patient’s quality of life. This article reviews the effects of down syndrome on craniomaxillofacial and oral manifestations and the corresponding treatments, in order to provide a reference basis for the clinical treatment and risk assessment.

Key words: Down syndrome, craniomaxillofacial characteristics, oral characteristics, treatment

CLC Number: 

  • R 782

TrendMD: 
1 Corona-Rivera JR, Martínez-Macías FJ, Bobadilla-Morales L, et al. Prevalence and risk factors for Down syndrome: a hospital-based single-center stu-dy in Western Mexico[J]. Am J Med Genet A, 2019, 179(3): 435-441.
2 MCPMDSilva, Lyra MCA, Almeida HCR, et al. Caries experience in children and adolescents with Down syndrome: a systematic review and meta-analysis[J]. Arch Oral Biol, 2020, 115: 104715.
3 Matos J, Vieira A, Franco J, et al. Cephalometric characteristics of down syndrome in Brazilian population[J]. Br J Med Med Res, 2016, 17(5): 1-7.
4 Vicente A, Bravo-González LA, López-Romero A, et al. Craniofacial morphology in down syndrome: a systematic review and meta-analysis[J]. Sci Rep, 2020, 10(1): 19895.
5 Baus-Domínguez M, Gómez-Díaz R, Corcuera-Flores JR, et al. Metallothioneins in failure of dental implants and periodontitis down syndrome patients[J]. Genes (Basel), 2019, 10(9): 711.
6 Doriguêtto PVT, Carrada CF, Scalioni FAR, et al. Malocclusion in children and adolescents with Down syndrome: a systematic review and meta-analysis[J]. Int J Paediatr Dent, 2019, 29(4): 524-541.
7 Ghaith B, Al Halabi M, Khamis AH, et al. Oral health status among children with down syndrome in Dubai, united Arab emirates[J]. J Int Soc Prev Community Dent, 2019, 9(3): 232-239.
8 Takizawa H, Takahashi M, Maki K. Three-dimensional assessment of craniofacial features in patients with down syndrome during the mixed dentition period: a case-control study[J]. Cleft Palate Craniofac J, 2022, 59(2): 177-184.
9 Weichert J, Gembicki M, Ribbat-Idel J, et al. Assessment of midfacial hypoplasia in down syndrome fetuses-validity of a two-line approach and introduction of a novel angle (maxilla-mandible-nasion angle)[J]. Ultrasound Int Open, 2016, 2(2): E58-E62.
10 Andersson EM, Axelsson S, Katsaris KP. Malocclusion and the need for orthodontic treatment in 8-year-old children with Down syndrome: a cross-sectional population-based study[J]. Spec Care Dentist, 2016, 36(4): 194-200.
11 Palaska PK, Antonarakis GS. Prevalence and patterns of permanent tooth agenesis in individuals with Down syndrome: a meta-analysis[J]. Eur J Oral Sci, 2016, 124(4): 317-328.
12 de Santis D, Sinigaglia S, Faccioni P, et al. Syndromes associated with dental agenesis[J]. Minerva Stomatol, 2019, 68(1): 42-56.
13 Gallo C, Pastore I, Beghetto M, et al. Symmetry of dental agenesis in Down syndrome children[J]. J Dent Sci, 2019, 14(1): 61-65.
14 Sekerci AE, Cantekin K, Aydinbelge M, et al. Prevalence of dental anomalies in the permanent dentition of children with Down syndrome[J]. J Dent Child (Chic), 2014, 81(2): 78-83.
15 Mestrović SR, Rajić Z, Papić JS. Hypodontia in patients with Down’s syndrome[J]. Coll Antropol, 1998, 22 (): 69-72.
16 Delabar JM, Theophile D, Rahmani Z, et al. Mole-cular mapping of twenty-four features of Down syndrome on chromosome 21[J]. Eur J Hum Genet, 1993, 1(2): 114-124.
17 Ruy Carneiro NC, de Castro Souza I, Duda Deps Almeida T, et al. Risk factors associated with reported bruxism among children and adolescents with Down syndrome[J]. Cranio, 2020, 38(6): 365-369.
18 Guo HQ, Wang TX, Li XC, et al. What sleep beha-viors are associated with bruxism in children? A systematic review and meta-analysis[J]. Schlaf Atmung, 2017, 21(4): 1013-1023.
19 Serra-Negra JM, Ribeiro MB, Prado IM, et al. Association between possible sleep bruxism and sleep characteristics in children[J]. Cranio, 2017, 35(5): 315-320.
20 de Moraes Pini D, Fröhlich PCGR, Rigo L. Oral health evaluation in special needs individuals[J]. Einstein (Sao Paulo), 2016, 14(4): 501-507.
21 Nuernberg MAA, Ivanaga CA, Haas AN, et al. Pe-riodontal status of individuals with Down syndrome: sociodemographic, behavioural and family perception influence[J]. J Intellect Disabil Res, 2019, 63(10): 1181-1192.
22 Subramaniam P, Babu KG, Das LM. Assessment of salivary total antioxidant levels and oral health status in children with Down syndrome[J]. Spec Care Dentist, 2014, 34(4): 193-200.
23 Hashizume LN, Schwertner C, Moreira MJS, et al. Salivary secretory IgA concentration and dental ca-ries in children with Down syndrome[J]. Spec Care Dentist, 2017, 37(3): 115-119.
24 Lugović-Mihić L, Pilipović K, Crnarić I, et al. Differential diagnosis of cheilitis-how to classify cheilitis[J]. Acta Clin Croat, 2018, 57(2): 342-351.
25 Shukla D, Bablani D, Chowdhry A, et al. Dentofacial and cranial changes in down syndrome[J]. O-song Public Health Res Perspect, 2014, 5(6): 339-344.
26 Foersch M, Jacobs C, Wriedt S, et al. Effectiveness of maxillary protraction using facemask with or without maxillary expansion: a systematic review and meta-analysis[J]. Clin Oral Investig, 2015, 19(6): 1181-1192.
27 Matthews-Brzozowska T, Cudziło D, Walasz J, et al. Rehabilitation of the orofacial complex by means of a stimulating plate in children with Down syndrome[J]. Adv Clin Exp Med, 2015, 24(2): 301-305.
28 Law J, Dornstauder M, Charlton J, et al. Tele-practice for children and young people with communication disabilities: employing the COM-B model to review the intervention literature and inform guidance for practitioners[J]. Int J Lang Commun Disord, 2021, 56(2): 415-434.
29 Stojanovik V, Pagnamenta E, Seager E, et al. The ASCEND study: protocol for a feasibility study to evaluate an early social communication intervention for young children with Down syndrome[J]. Pilot Feasibility Stud, 2022, 8(1): 8.
30 Mat Zin S, Md Rasib SZ, Suhaimi FM, et al. The technology of tongue and hard palate contact detection: a review[J]. Biomed Eng Online, 2021, 20(1): 17.
31 Jackson A, Maybee J, Wolter-Warmerdam K, et al. Associations between age, respiratory comorbidities, and dysphagia in infants with down syndrome[J]. Pediatr Pulmonol, 2019, 54(11): 1853-1859.
32 Wintergerst A, López-Morales MP. Masticatory function in children with Down syndrome[J]. Phy-siol Behav, 2021, 235: 113390.
33 Paul Y, Ellapen TJ, Barnard M, et al. The health be-nefits of exercise therapy for patients with Down syndrome: a systematic review[J]. Afr J Disabil, 2019, 8: 576.
34 Nation J, Brigger M. The efficacy of adenotonsillectomy for obstructive sleep apnea in children with down syndrome: a systematic review[J]. Otolaryngol Head Neck Surg, 2017, 157(3): 401-408.
35 Poumeaud F, Mircher C, Smith PJ, et al. Deciphe-ring the links between psychological stress, depression, and neurocognitive decline in patients with Down syndrome[J]. Neurobiol Stress, 2021, 14: 10-0305.
36 Dafsari FS, Jessen F. Depression-an underrecognized target for prevention of dementia in Alzhei-mer’s disease[J]. Transl Psychiatry, 2020, 10(1): 160.
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