Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (2): 197-203.doi: 10.7518/gjkq.2022025

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Research progress on the dentin bone repair material

Li Yanfei(),Zhang Xinchun()   

  1. Dept. of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
  • Received:2021-08-05 Revised:2021-11-12 Online:2022-03-01 Published:2022-03-15
  • Contact: Xinchun Zhang E-mail:liyf273@mail2.sysu.edu.cn;zhxinch@mail.sysu.edu.cn
  • Supported by:
    Natural Science Foundation of Guangdong Province(2019A1515010450);Guangzhou Science and Technology Program(202002030055)

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Abstract:

Various events can cause oral bone loss, which results in the dysfunction of oral and maxillofacial area and difficulties in oral rehabilitation. Therefore, a new osteogenic material possesses excellent osteoconductivity, osteoinductivity, biocompatibility, and absorbability. Dentin has been widely explored as a novel bone repair material, which can be obtained from a wide range of sources such as waste or impacted teeth. It shares the same neural crest embryonic origin with a maxillofacial bone and resembles each other in physiochemical characteristics, which give dentin a natural advantage to promote bone regeneration. Dentin is also a storage of various bioactive molecules and growth factors. A great number of animal studies have shown that dentin can induce bone regeneration. Numerous successful clinical outcomes of dentin have been reported when it is used in a variety of therapies. This review aims to introduce the bone formation mechanism, preparation procedure, and clinical application of dentin bone repair material and provide further theoretical basis for its use.

Key words: dentin, bone repair material, bone defect, osteoinduction, bone regeneration

CLC Number: 

  • R782

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