Int J Stomatol

Inter J Stomatol ›› 2010, Vol. 37 ›› Issue (5): 516-518.doi: 10.3969/j.issn.1673-5749.2010.05.006

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Relationship between nonsyndromic cleft lip with or without cleft palate and genetic polymorphisms of muscle segment homeobox gene-1 A448T

XIE Geng-yun, NAN Xin-rong, LI Dian-dian.   

  1. Dept. of Stomatology, The First Hospital, Shanxi Medical University, Taiyuan 030001, China
  • Online:2010-09-20 Published:2010-09-20

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Abstract:

Objective To explore the relationship between nonsyndromic cleft lip with or without cleft palate （NSCL/P） and genetic polymorphism of muscle segment homeobox gene（msx）-1 A448T in Shanxi province population. Methods Case-control study design was employed. msx-1 genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism techniques. Results It was obvious difference between NSCL/P group and control group in msx-1 A448T mutation allele（T） frequency（P<0.01）. The frequency of allele （T） of control group was higher than NSCL/P group（0.55>0.26）. Conclusion We could confirm a significant association between msx-1/A448T polymorphism and NSCL/P in Shanxi province, China. T allele has protective effect in NSCL/P occurrence.

Key words: msx-1 gene, nonsyndromic cleft lip with or without cleft palate, genetic polymorphism


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