Int J Stomatol

Inter J Stomatol ›› 2017, Vol. 44 ›› Issue (5): 523-527.doi: 10.7518/gjkq.2017.05.006

• Periodontitis • Previous Articles     Next Articles

The effect of epigenetics and its regulation on periodontal disease

Liu Shuang, Li Shu.   

  1. Dept. of Periodontics, Hospital of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China
  • Received:2016-11-23 Revised:2017-05-26 Online:2017-09-01 Published:2017-09-01

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Abstract: Epigenetics is defined as not involved in the change of the DNA sequence, but through mitosis and meiosis of the genetic changes in the genetics of the field, and its regulatory mechanisms include DNA methylation, histone modification, chromatin remodeling and non-encoding RNA regulation. The pathogeny of periodontal disease is complex, and it is difficult to achieve functional regeneration of alveolar bone. Epigenetic plays an important role in the development of inflammation and the promotion of bone regeneration. It will be an important research field in the future and have important clinical significance to prevent the occurrence of periodontal disease and make the functional regeneration of alveolar bone possible from the perspective of the epigenetic and its regulation.

Key words: epigenetics, periodontics, alveolar bone regeneration

CLC Number: 

  • R781.4

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