Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (6): 703-710.doi: 10.7518/gjkq.2021110

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Effects of parathyroid hormone and parathyroid hormone-related peptide on hard dental tissue formation

Li Yuan-yuan(),Chen Junyu,Cai He,Wan Qianbing()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-02-21 Revised:2021-07-02 Online:2021-11-01 Published:2021-10-28
  • Contact: Qianbing Wan E-mail:2962025647@qq.com;champion@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(81970984)

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Abstract:

Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) are critical regulators of calcium and phosphorus balance, which affects the formation and mineralization of tooth tissue. PTHrP, as the growth factor that mediates epithelial-mesenchymal interaction, plays an important role in regulating the proliferation and differentiation of tooth germ cells in an autocrine or paracrine manner. This review provides an overview of the effects of parathyroid hormone and PTHrP on the formation and mineralization of hard dental tissue, which could be beneficial to their potential applications in dental abnormalities and hard tissue defect.

Key words: parathyroid hormone, parathyroid hormone-related peptide, tooth hard tissue, mineralization

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  • R78

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