Int J Stomatol

Inter J Stomatol ›› 2019, Vol. 46 ›› Issue (2): 186-190.doi: 10.7518/gjkq.2019023

• Periodontal Diseases • Previous Articles     Next Articles

Research progress on inflammasome in periodontitis

Huixin Lü1,Liuyi Du1,Yao Wang1,Weixian Yu2,Jingyi Ren1,Xinming Gu1,Yanmin Zhou1()   

  1. 1. Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China)
  • Received:2018-06-30 Revised:2018-11-10 Online:2019-03-01 Published:2019-03-15
  • Contact: Yanmin Zhou E-mail:Zhouym62@163.com
  • Supported by:
    This study was supported by National Natural Science Fundation of China(81570983);Postgraduate Innovation Fund Project of Jilin University(2017014)

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Abstract:

Inflammasome is a multi-protein complex that exists in the cytoplasm and is involved in innate immune response. This multi-protein oligomer can activate proinflammatory cytokines such as interleukin-1β, mediate cell death, and regulate the progression of inflammation. Periodontitis is an inflammatory and destructive disease caused by various periodontal pathogens, such asPorphyromonas gingivalis. Bacteria and their toxic components can cause the assembly of various inflammasomes and eventually destroy periodontal tissues. This review focuses on the production of inflammasomes in periodontitis and its mechanism of causing diseases.

Key words: periodontitis, inflammasome, pyroptosis, interleukin

CLC Number: 

  • R781.4 +2

TrendMD: 
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