Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (2): 192-198.doi: 10.7518/gjkq.2018.02.012

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Application of nano-hydroxyapatite in the clinical treatment of oral diseases

Luo Weidan, Li Mingyun, Zhou Xuedong, Cheng Lei   

  1. State Key Laboratory of Oral Diseases &National Clinical Research Center for Oral Diseases &Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-08-31 Revised:2017-12-20 Online:2018-03-01 Published:2018-03-01
  • Supported by:
    This study was supported by International Science and Technology Cooperation Program of China (2014DFE30180).

Abstract: Nano-hydroxyapatite (nHA) shows a structure similar to that of hydroxyapatite crystal in human bone tissue and tooth enamel. Given its excellent physical and chemical properties, biocompatibility and osseointegration, nHA has been extensively applied in the clinical treatment of oral diseases. This article reviewed the most recent findings about nHA in stomatology, including the modification of restorative materials, tooth remineralization, tooth desensitization, pulp canal therapy and pulp tissue engineering. These studies are indicative of the future remarkable significance of nHA in stomatology.

Key words: nano-hydroxyapatite, material modification, remineralization, desensitization, pulp canal therapy, pulp tissue engineering

CLC Number: 

  • R781.05

TrendMD: 
[1] 李平, 肖丽英, 李伟, 等. 新型纳米羟基磷灰石根充糊剂的细胞毒性研究[J]. 华西口腔医学杂志, 2005, 23(5):427-430.
Li P, Xiao LY, Li W, et al.Evaluation on cytotoxi-city of a new nano-hydroxyapatite as root canal filling sealer[J]. West Chin J Stomatol, 2005, 23(5): 427-430.
[2] Chen L, Mccrate JM, Lee JC, et al.The role of sur-face charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cells[J]. Nanotechnology, 2011,22(10):105708.
[3] Antonova IN, Goncharov VD, Kipchuk AV, et al.Peculiarities of the morphological structure of the inorganic component of human dental enamel and dentin at nano-level[J]. Morfologiia, 2014, 146(5): 52-56.
[4] Parayanthala Valappil M, Santhakumar S, Arumu-gam S. Determination of oxidative stress related toxicity on repeated dermal exposure of hydroxya-patite nanoparticles in rats[J]. Int J Biomater, 2014, 2014:476942.
[5] Zhang H, Darvell BW.Mechanical properties of hydroxyapatite whisker-reinforced bis-GMA-based resin composites[J]. Dent Mater, 2012, 28(8):824-830.
[6] Liu W, He XP, Mo AC, et al.Investigation of the mechanical properties of a low-shrinkage liquid crystalline matrix combined with nano-hydroxya-patite[J]. Int J Nanomed, 2011, 6:1787-1791.
[7] 赵蒙蒙, 王青山, 王爽, 等. 自制纳米羟磷灰石复合树脂与牙体之间微渗漏的实验研究[J]. 华西口腔医学杂志, 2013, 31(3):300-302.
Zhao MM, Wang QS, Wang S, et al.Experimental study on microleakage between a new nano-hydro-xyapatite composite and tooth[J]. West Chin J Sto-matol, 2013, 31(3):300-302.
[8] Enan ET, Hammad SM.Microleakage under ortho-dontic bands cemented with nano-hydroxyapatite-modified glass ionomer[J]. Angle Orthod, 2013, 83(6):981-986.
[9] Choudhary K, Nandlal B.Comparative evaluation of shear bond strength of nano-hydroxyapatite incor-porated glass ionomer cement and conventional glass ionomer cement on dense synthetic hydroxyapatite disk: an in vitro study[J]. Indian J Dent Res, 2015, 26(2):170-175.
[10] Lee JJ, Lee YK, Choi BJ, et al.Physical properties of resin-reinforced glass ionomer cement modified with micro and nano-hydroxyapatite[J]. J Nanosci Nanotechnol, 2010, 10(8):5270-5276.
[11] Zakir M, Al Kheraif AA, Asif M, et al.A com-parison of the mechanical properties of a modified silorane based dental composite with those of com-mercially available composite material[J]. Dent Mater, 2013, 29(4):e53-e59.
[12] Chen L, Yu Q, Wang Y, et al.BisGMA/TEGDMA dental composite containing high aspect-ratio hydro-xyapatite nanofibers[J]. Dent Mater, 2011,27(11): 1187-1195.
[13] Lung CY, Sarfraz Z, Habib A, et al.Effect of si-lanization of hydroxyapatite fillers on physical and mechanical properties of a bis-GMA based resin composite[J]. J Mech Behav Biomed Mater, 2016, 54:283-294.
[14] Sadat-Shojai M, Atai M, Nodehi A, et al.Hydroxya-patite nanorods as novel fillers for improving the properties of dental adhesives: synthesis and app-lication[J]. Dent Mater, 2010, 26(5):471-482.
[15] Lezaja M, Veljovic DN, Jokic BM, et al.Effect of hydroxyapatite spheres, whiskers, and nanoparticles on mechanical properties of a model BisGMA/TEG DMA composite initially and after storage[J]. J Bio-med Mater Res Part B Appl Biomater, 2013, 101(8):1469-1476.
[16] Deyhle H, Bunk O, Müller B.Nanostructure of heal-thy and caries-affected human teeth[J]. Nanome-dicine, 2011, 7(6):694-701.
[17] Krishnan V, Bhatia A, Varma H.Development, cha-racterization and comparison of two strontium doped nano hydroxyapatite molecules for enamel repair/regeneration[J]. Dent Mater, 2016, 32(5):646-659.
[18] Besinis A, van Noort R, Martin N. Infiltration of demineralized dentin with silica and hydroxyapatite nanoparticles[J]. Dent Mater, 2012, 28(9):1012-1023.
[19] Huang SB, Gao SS, Yu HY.Effect of nano-hydro-xyapatite concentration on remineralization of initial enamel lesion in vitro[J]. Biomed Mater, 2009, 4(3): 034104.
[20] Ma G, Liu XY, Wang M.Growth and mechanisms of enamel-like hierarchical nanostructures on single crystalline hydroxyapatite micro-ribbons[J]. J Nano-sci Nanotechnol, 2011, 11(6):5199-5206.
[21] Samuel SR, Dorai S, Khatri SG, et al.Effect of ozone to remineralize initial enamel caries: in situ study[J]. Clin Oral Investig, 2016, 20(5):1109-1113.
[22] Huang S, Gao S, Cheng L, et al.Combined effects of nano-hydroxyapatite and Galla chinensis on re-mineralisation of initial enamel lesion in vitro[J]. J Dent, 2010, 38(10):811-819.
[23] Huang S, Gao S, Cheng L, et al.Remineralization potential of nano-hydroxyapatite on initial enamel lesions: an in vitro study[J]. Caries Res, 2011, 45(5): 460-468.
[24] Souza BM, Comar LP, Vertuan M, et al.Effect of an experimental paste with hydroxyapatite nanoparticles and fluoride on dental demineralisation and remi-neralisation in situ[J]. Caries Res, 2015, 49(5): 499-507.
[25] Tschoppe P, Zandim DL, Martus P, et al.Enamel and dentine remineralization by nano-hydroxyapatite toothpastes[J]. J Dent, 2011, 39(6):430-437.
[26] de Carvalho FG, Vieira BR, Santos RL, et al. In vitro effects of nano-hydroxyapatite paste on initial ena-mel carious lesions[J]. Pediatr Dent, 2014, 36(3):85-89.
[27] Mielczarek A, Michalik J.The effect of nano-hydro-xyapatite toothpaste on enamel surface remineraliza-tion. An in vitro study[J]. Am J Dent, 2014, 27(6): 287-290.
[28] Vyavhare S, Sharma DS, Kulkarni VK.Effect of three different pastes on remineralization of initial enamel lesion: an in vitro study[J]. J Clin Pediatr Dent, 2015, 39(2):149-160.
[29] Najibfard K, Ramalingam K, Chedjieu I, et al.Re-mineralization of early caries by a nano-hydroxya-patite dentifrice[J]. J Clin Dent, 2011,22(5):139-143.
[30] Min JH, Kwon HK, Kim BI.Prevention of dental erosion of a sports drink by nano-sized hydroxya-patite in situ study[J]. Int J Paediatr Dent, 2015, 25(1):61-69.
[31] Min JH, Kwon HK, Kim BI.The addition of nano-sized hydroxyapatite to a sports drink to inhibit dental erosion: in vitro study using bovine enamel[J]. J Dent, 2011, 39(9):629-635.
[32] 王浙君, 撒悦, 马霄, 等. 纳米羟基磷灰石的制备及其对牙本质小管封闭效果的初步观察[J]. 中华口腔医学杂志, 2009, 44(5):297-300.
Wang ZJ, Sa Y, Ma X, et al.The preparation of nano-hydroxyapatite and preliminary observation on its effects on the occlusion of dentinal tubule[J]. Chin J Stomatol, 2009, 44(5):297-300.
[33] Gopinath NM, John J, Nagappan N, et al.Evaluation of dentifrice containing nano-hydroxyapatite for dentinal hypersensitivity: a randomized controlled trial[J]. J Int Oral Health, 2015, 7(8):118-122.
[34] Low SB, Allen EP, Kontogiorgos ED.Reduction in dental hypersensitivity with nano-hydroxyapatite, potassium nitrate, sodium monoflurophosphate and antioxidants[J]. Open Dent J, 2015, 9(1):92-97.
[35] Vano M, Derchi G, Barone A, et al.Tooth bleaching with hydrogen peroxide and nano-hydroxyapatite: a 9-month follow-up randomized clinical trial[J]. Int J Dent Hyg, 2015, 13(4):301-307.
[36] Collares FM, Leitune VC, Rostirolla FV, et al.Nanostructured hydroxyapatite as filler for me-thacrylate-based root canal sealers[J]. Int Endod J, 2012, 45(1):63-67.
[37] Aal-Saraj AB, Ariffin Z, Masudi SM.An agar dif-fusion study comparing the antimicrobial activity of Nanoseal with some other endodontic sealers[J]. Aust Endod J, 2012, 38(2):60-63.
[38] Swarup SJ, Rao A, Boaz K, et al.Pulpal response to nano hydroxyapatite, mineral trioxide aggregate and calcium hydroxide when used as a direct pulp capping agent: an in vivo study[J]. J Clin Pediatr Dent, 2014, 38(3):201-206.
[39] Yang X, Yang F, Walboomers XF, et al.The perfor-mance of dental pulp stem cells on nanofibrous PCL/gelatin/nHA scaffolds[J]. J Biomed Mater Res A, 2010, 93(1):247-257.
[40] Ling LE, Feng L, Liu HC, et al.The effect of calcium phosphate composite scaffolds on the osteogenic differentiation of rabbit dental pulp stem cells[J]. J Biomed Mater Res A, 2015, 103(5):1732-1745.
[41] van Manen EH, Zhang W, Walboomers XF, et al. The influence of electrospun fibre scaffold orien-tation and nano-hydroxyapatite content on the de-velopment of tooth bud stem cells in vitro[J]. Odon-tology, 2014, 102(1):14-21.
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