Int J Stomatol

Int J Stomatol ›› 2015, Vol. 42 ›› Issue (6): 715-719.doi: 10.7518/gjkq.2015.06.023

Previous Articles     Next Articles

Biological characteristics of stem cells from human-exfoliated deciduous teeth

Gu Nan, Sun Xin, Liu Fuping, Zhang Yuna, Zhang Xue, Li Haiying.   

  1. Dept. of Pediatric Dentistry, Hospital of Stomatology, School of Stomatology, Jilin University, Changchun 130021, China
  • Received:2014-12-04 Revised:2015-04-10 Online:2015-11-01 Published:2015-11-01

RichHTML

5

PDF (PC)

1566

Abstract:

Deciduous teeth are constantly exfoliated in the alternate process of deciduous and permanent teeth. Hence, obtaining stem cells from human-exfoliated deciduous teeth(SHED) is simple and convenient. The proliferation rate of SHED was significantly higher than that of dental pulp stem cells and bone marrow mesenchymal stem cells. SHED expressed several growth factors for promoting proliferation, such as fibroblast growth factor, transforming growth factor-β, connective tissue growth factor, nerve growth factor, and bone morphogenetic protein. SHED are able to differentiate into odontoblasts, neural cells, cartilage cells, adipocytes, and liver cells, and can induce host cells to regenerate bone. In addition, SHED have immune modulatory effects and can enhance wound-healing effects. SHED are ideal seed cells for bone and skin tissue engineering. Thus, SHED can potentially be used for treating tooth and bone defects, nervous system diseases, immune system diseases, skin trauma, and liver diseases.

Key words: stem cell from human exfoliated deciduous teeth, multilineage differentiation, tissue regeneration

CLC Number: 

  • Q 256

TrendMD: 
[1] Wang Jiaxi,Mingyue Lü,Yuan Quan. Research progress on sticky bone in oral tissue regeneration [J]. Int J Stomatol, 2023, 50(5): 594-602.
[2] Fan Lin,Sun Jiang.. Application of microneedles in stomatology [J]. Int J Stomatol, 2023, 50(4): 472-478.
[3] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontics microsurgery: clinical protocol and practical cases (part 2) [J]. Int J Stomatol, 2022, 49(6): 621-632.
[4] Man Yi, Huang Dingming. Combined treatment strategy of oral implantology and endodontic microsurgery for bone augmentation and en-dodontic diseases in aesthetic area (part 1): application basis and indications [J]. Int J Stomatol, 2022, 49(5): 497-505.
[5] Li Pei,Lin Ling,Zhao Wei.. Research progress on the stem cells from human exfoliated deciduous teeth in the regeneration and repair of oral tissue [J]. Int J Stomatol, 2022, 49(4): 483-488.
[6] Zhao Wenjun,Chen Yu. Research progress on periodontal functional gradient membrane for guided tissue/bone regeneration [J]. Int J Stomatol, 2021, 48(4): 391-397.
[7] Wang Shiqi,Chang Yaqin,Chen Bin,Tan Baochun,Ni Yanhong. Comparison of clinical outcomes between using bone graft alone and the combination of bone graft with membrane for periodontal regeneration therapy: a systematic review and Meta-analysis [J]. Int J Stomatol, 2020, 47(6): 644-651.
[8] Sun Zhaoze,Liu Shuang,Li Shu. Axon guidance molecules and their role in oral tissue regeneration [J]. Int J Stomatol, 2019, 46(6): 680-686.
[9] Tingting Jia,Shiguo Yan. Research progress on the role of special AT-rich sequence binding protein 2 in maxillofacial development and perio-dontal regeneration [J]. Int J Stomatol, 2019, 46(3): 320-325.
[10] Zhengmou Dong,Rui Liu,Luchuan Liu,Xiujie Wen. Research progress on the seed cells in periodontal tissue regeneration [J]. Inter J Stomatol, 2019, 46(1): 48-54.
[11] Jiangxue Tian,Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xin. Xu. Role of transforming growth factor-β in periodontitis [J]. Inter J Stomatol, 2018, 45(5): 553-559.
[12] Lin Yunfeng, Li Songhang. Research progress on application of DNA origami in stem cell field [J]. Inter J Stomatol, 2018, 45(3): 249-254.
[13] Liu Zhenzhen, Fang Jiao, Zhao Jinghui, Zou Jingting, Xiang Xingchen, Wang Jia, Zhou Yanmin. A review on recent developments in pluripotency of gingiva-derived mesenchymal stem cells [J]. Inter J Stomatol, 2018, 45(1): 55-58.
[14] Guan Wei, Wang Changning.. Application of acellular dermal matrix in periodontology [J]. Inter J Stomatol, 2017, 44(6): 669-673.
[15] Li Xinyi, Dong Wei. Enamel matrix protein in enhancing periodontal tissue regeneration [J]. Inter J Stomatol, 2015, 42(5): 600-605.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .