Int J Stomatol

Int J Stomatol ›› 2015, Vol. 42 ›› Issue (6): 710-714.doi: 10.7518/gjkq.2015.06.022

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Nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 inflammasomes and the relationship between it and periodontal diseases

Wu Leng, Wang Jun, Zhao Lei, Wu Yafei.   

  1. State Key Laboratory of Oral Diseases, Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2014-12-02 Revised:2015-05-23 Online:2015-11-01 Published:2015-11-01

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Abstract:

The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing(NLRP)3 inflammasome is an intracellular multi-protein complex that is assembled after its central component, NLRP3, and senses pathogens and host danger signals. The NLRP3 inflammasome induces maturation and secretion of inflammatory cytokines interleukin(IL)-1β by activating cysteinyl aspartale specific protease-1, thereby participating in immunoinflammatory responses. Periodontal diseases are caused by local immunoinflammatory responses against periodontal pathogens, with IL-1β being one of the critical factors. Furthermore, the processing and secretion of IL-1β is closely related to the NLRP3 inflammasome. Periodontal pathogens can regulate expression and activation of NLRP3 inflammasome. Therefore, NLRP3 inflammasome is significant to the development and treatment of periodontal diseases. This article focuses on the biological function and activation mechanism of the NLRP3 inflammasome and the relevant research progress on periodontal diseases.

Key words: inflammasomes, nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3, cysteinylaspartale specific protease-1, interleukin, periodontal disease, immunoinflammatory responses

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  • Q 51

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