纤维蛋白原血管外沉积在黏膜免疫中作用的研究进展

doi:10.7518/gjkq.2023060

摘要/Abstract

摘要：

纤维蛋白原是一种由肝脏合成的凝血因子，作为血浆蛋白在止血中发挥着重要作用。然而，当局部血管通透性增高时，纤维蛋白原可溢出形成血管外沉积，通过与细胞表面整合素受体相互识别，发挥趋化白细胞聚集，激活免疫反应的作用。研究表明：纤维蛋白原血管外沉积与一系列严重的黏膜疾病密切相关，包括口腔扁平苔藓（OLP）、口腔白斑病（OLK）、牙周炎、结膜炎、消化道和肺部炎症等，是潜在的临床治疗靶点。本文回顾了纤维蛋白原血管外沉积与黏膜免疫的相关研究进展，以期为研发新的临床治疗方法提供思考。

关键词: 纤维蛋白原, 黏膜免疫, 炎症

Abstract:

Fibrinogen is a member of coagulation factors synthesized by liver, and it plays an important role in hemostasis. However, in the case of increased vascular permeability, fibrinogen extravasates and accumulates outside blood vessels. Recognized by integrin receptors on the cell surface, extravascular deposited fibrinogen acts as an immune regulator by mediating leukocyte engagement and activation. Current studies suggest the close association of fibrinogen extravascular deposition with a series of severe mucosal diseases, including oral lichen planus (OLP), oral leukoplakia (OLK), pe-riodontitis, conjunctivitis, and inflammation of digestive tract and lung. This association is indicated to be a potential target for clinical therapy. This article reviewed the recent research progress regarding the relationship between extravascular fibrinogen deposition and mucosal immunity to provide motivations for the development of novel therapeutic methods.

Key words: fibrinogen, mucosal immunity, inflammation

中图分类号:

R 392.11

杨晓宇,袁泉. 纤维蛋白原血管外沉积在黏膜免疫中作用的研究进展[J]. 国际口腔医学杂志, 2023, 50(4): 457-462.

Yang Xiaoyu,Yuan Quan.. Research progress on the role of extravascular fibrinogen deposition in mucosal diseases[J]. Int J Stomatol, 2023, 50(4): 457-462.

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