腺苷酸活化蛋白激酶在牙周病发生发展中的研究进展

doi:10.7518/gjkq.2022059

摘要/Abstract

摘要：

牙周病是以特殊致病菌和破坏性免疫反应相互作用导致的牙周支持组织病理性吸收为特征。腺苷酸活化蛋白激酶（AMPK）作为关键的能量调节因子，通过参与调节重要组织器官脂肪酸和葡萄糖的代谢，从而维持身体内环境的稳态，在代谢性疾病中已被广泛研究。AMPK也可以通过参与牙周骨代谢、免疫反应、基质金属蛋白酶的分泌以及细胞自噬的调节来调控牙周病的发生和发展，在牙周病发病机制中具有潜在作用，并为牙周病的治疗提供了新的治疗靶点。本文对AMPK及其在牙周病发病机制中的研究进展做一综述。

关键词: 牙周病, 腺苷酸活化蛋白激酶, 基质金属蛋白酶, 炎症, 自噬

Abstract:

Periodontal disease is characterized by the pathological resorption of periodontal support tissue caused by the interaction of specific pathogenic bacteria and destructive immune response. As a key regulator of cellular energy, adenosine monophosphate-activated protein kinase (AMPK) participates in the regulation of the metabolism of fatty acids and glucose in important tissues and organs to maintain body homeostasis, and it has been studied extensively in metabolic diseases. Previous studies showed that AMPK can also participate in regulating periodontal bone metabolism, immune response, matrix metalloproteinase secretion, and cellular autophagy to regulate the occurrence and development of periodontal diseases, revealing the potential role of AMPK in the pathogenesis of periodontal disease and providing a new therapeutic target for its treatment. This review provides an overview of the research progress of AMPK in periodontal diseases.

Key words: periodontal disease, adenosine monophosphate-activated protein kinase, matrix metalloproteinases, inflammation, autophagy

中图分类号:

R 781.4

李归平,秦旭,朱光勋. 腺苷酸活化蛋白激酶在牙周病发生发展中的研究进展[J]. 国际口腔医学杂志, 2022, 49(3): 343-348.

Li Guiping,Qin Xu,Zhu Guangxun.. Research progress on adenosine monophosphate-activated protein kinase in periodontal disease[J]. Int J Stomatol, 2022, 49(3): 343-348.

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