国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (3): 329-334.doi: 10.7518/gjkq.2023030

• 综述 • 上一篇    下一篇

白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展

孙佳1(),韩烨2,侯建霞2()   

  1. 1.天津市口腔医院·南开大学医学院 天津市口腔功能重建重点实验室 天津 300041
    2.北京大学口腔医学院·口腔医院牙周科;国家口腔医学中心 国家口腔疾病临床医学研究中心;口腔数字化医疗技术和材料国家工程实验室 北京 100081
  • 收稿日期:2022-10-05 修回日期:2023-01-02 出版日期:2023-05-01 发布日期:2023-05-16
  • 通讯作者: 侯建霞
  • 作者简介:孙佳，主治医师，硕士，Email：kqyyyzsj@163.com
  • 基金资助:
    国家自然科学基金(82071117);北京市自然科学基金(7212136);天津市卫生健康科技项目(TJWJ2022QN073)

Research progress on the role of interleukin-6-hepcidin signal axis in regulating the pathogenesis of periodontitis-associated anemia

Sun Jia1(),Han Ye2,Hou Jianxia2()   

  1. 1.Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China
    2.Dept. of Periodontics, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Cli-nical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing 100081, China
  • Received:2022-10-05 Revised:2023-01-02 Online:2023-05-01 Published:2023-05-16
  • Contact: Jianxia Hou
  • Supported by:
    National Natural Science Foundation of China(82071117);Natural Science Foundation of Beijing(7212136);Health Science and Technology Project of Tianjin(TJWJ2022QN073)

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摘要：

牙周炎是由细菌感染引起的慢性感染性疾病，大量致病微生物及其毒性产物激活宿主防御系统，引起一系列免疫炎症反应，进而影响全身健康状况。牙周炎是很多系统性疾病的危险因素。炎症性贫血又称慢性病贫血，是临床上第二大常见贫血，其发生源于急性或慢性炎症状态，如感染、炎症或肿瘤等基础疾病。这些疾病可激活宿主防御系统，导致全身铁代谢紊乱，造成铁限制性血红蛋白生成障碍。牙周炎与炎症性贫血存在密切相关性，牙周炎引起的全身免疫炎症反应可能会增加罹患炎症性贫血的风险，白细胞介素-6-铁调素信号轴可能在牙周炎相关炎症性贫血的致病机制中起到关键的调控作用。本文就近年来牙周炎与炎症性贫血的相关性和机制等研究进行综述，以期为牙周炎相关炎症性贫血的预防、诊断和治疗提供依据。

关键词: 牙周炎, 炎症性贫血, 铁代谢, 铁调素, 白细胞介素-6

Abstract:

Periodontitis is a chronic inflammatory disease initiated by bacterial infection. The pathogenic micro-organisms and their toxic products activate the host defense system and evoke immune-inflammatory responses, which affect systemic health. Periodontitis is a risk factor for many systemic diseases. Anemia of inflammation (AI), the second most prevalent type of anemia, occurs in chronic or acute infections and manifests as infection, inflammation, or tumor. These diseases activate the host defense system, resulting in systemic iron disorder and iron-restricted hemoglobin production disorders. A close association exists between AI and periodontitis, but the potential mechanism remains unclear. The interleukin-6-hepcidin signal axis is suggested to play a central role. This paper discusses the recent findings of the asso-ciation between AI and periodontitis to provide theoretical basis and clinical guidance for the prevention, diagnosis, and treatment of periodontitis-associated AI.

Key words: periodontitis, anemia of inflammation, iron metabolism, hepcidin, interleukin-6

中图分类号: 

  • R 781.4
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