微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制

doi:10.7518/gjkq.2022051

摘要/Abstract

摘要：

牙周炎是一种以牙周袋形成和牙槽骨吸收为特征的炎症性疾病，是40岁以上成人牙齿脱落的主要原因之一。牙周组织产生的龈沟液可以一定程度的揭示牙周的状态，其中的微小RNA（miRNA）的表达水平会根据牙周炎症的发展发生改变，可以作为牙周诊断的指标之一。miR-146a及miR-223是牙周炎进展中表达水平显著变化的miRNA，它们是目前利用龈沟液miRNA对牙周炎诊断最有潜力的生物标志物。不同miRNA可以通过调控牙周炎信号通路的不同阶段发挥作用，如通过细菌脂多糖与Toll样受体的结合、核因子κB配体信号通路及炎症因子的释放等过程调控牙周炎症进程。本文就牙周炎龈沟液中miRNA的表达差异及调控机制作一综述，以期为龈沟液miRNA准确诊断牙周炎提供新思路和新进展。

关键词: 龈沟液, 微小RNA, 牙周炎, Toll样受体, 核因子κB配体

Abstract:

Periodontitis is an inflammatory disease characterised by the formation of periodontal pocket and the resorption of alveolar bone. It is the main cause of tooth loss in adults over 40 years old. The gingival crevicular fluid produced by the periodontal tissue can reflect the state of periodontal inflammation to a certain extent, and the expression level of microRNA (miRNA) in it changes according to the progression of periodontal inflammation, which can be used as an indicator of periodontal diagnosis. The expression levels of miR-146a and miR-223 can be altered significantly during perio-dontitis progression. They are currently the most potential biomarkers periodontitis diagnosis by using miRNA in gingival crevicular fluid. Different miRNAs can play different roles by regulating the different stages of the periodontitis signalling pathway, such as the binding of bacterial lipopolysaccharide and Toll-like receptor, nuclear factor-κB ligand signalling pathway, and the release of inflammatory factors. This review elaborates the expression differences and modulation mechanisms of miRNA in periodontitis gingival crevicular fluid with a view to offer novel insights and strategies for the accurate diagnosis of periodontitis by miRNA in gingival crevicular fluid.

Key words: gingival crevicular fluid, microRNA, periodontitis, Toll-like receptor, nuclear factor-κB ligand

中图分类号:

R 781.4

钱素婷,丁玲敏,纪雅宁,林军. 微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制[J]. 国际口腔医学杂志, 2022, 49(3): 349-355.

Qian Suting,Ding Lingmin,Ji Yaning,Lin Jun.. Differential expression of microRNA in gingival crevicular fluid of periodontitis and its regulatory mechanism on periodontitis[J]. Int J Stomatol, 2022, 49(3): 349-355.

图/表 1

图 1

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