国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (5): 586-592.doi: 10.7518/gjkq.2022070

• 综述 • 上一篇    下一篇

辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展

周剑鹏(),谢旭东,赵蕾,王骏()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科 成都 610041
  • 收稿日期:2021-11-18 修回日期:2022-04-25 出版日期:2022-09-01 发布日期:2022-09-16
  • 通讯作者: 王骏
  • 作者简介:周剑鹏，硕士，Email：jpzhou96@163.com
  • 基金资助:
    国家自然科学基金(82071127);四川省科技计划项目(2019YJ0097)

Research progress on the roles and mechanisms of T-helper 17 cells and interleukin-17 in periodontitis

Zhou Jianpeng(),Xie Xudong,Zhao Lei,Wang Jun.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-11-18 Revised:2022-04-25 Online:2022-09-01 Published:2022-09-16
  • Contact: Jun. Wang
  • Supported by:
    National Natural Science Foundation of China(82071127);Sichuan Province Science and Technology Support Program(2019YJ0097)

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摘要：

牙周炎是以菌斑生物膜为始动因子的慢性感染性疾病，牙周支持组织破坏为其主要特征。菌斑生物膜定植引发的宿主免疫反应在牙周炎发生发展中起决定性作用。辅助性T细胞17（Th17）及其主要产生的促炎细胞因子白细胞介素17（IL-17）已被证实在牙周炎中发挥重要作用。牙周炎患者局部病损中Th17细胞浸润和IL-17分泌量增加，并且其增加量和牙周炎严重程度相关。本文旨在对Th17细胞及其分泌的IL-17在牙周炎中的作用及机制的研究进展进行综述。

关键词: 辅助性T细胞17, 细胞因子, 白细胞介素17, 牙周炎, 免疫反应

Abstract:

Periodontitis is a chronic infectious disease characterized by the destruction of periodontal supporting tissues, and plaque biofilms have been identified as the initial factors. Host immune response triggered by the colonization of plaque biofilms plays a critical role in the occurrence and development of periodontitis. T-helper 17 cells (Th17) and their main pro-inflammatory cytokine interleukin-17 (IL-17) are indispensable in periodontitis. Previous studies have de-monstrated increased infiltration of Th17 cell and a high level of IL-17 in periodontal lesions, and the increased levels are related to the severity of periodontitis. This review article aims to summarize progress in research on the roles and mechanisms of Th17 cells and IL-17 in periodontitis.

Key words: T-helper 17 cell, cytokine, interleukin-17, periodontitis, immune response

中图分类号: 

  • R 781.4+2

图 1

Th17细胞和IL-17在牙周组织破坏中的作用"

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