国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (1): 25-31.doi: 10.7518/gjkq.2023013

• 牙周专栏 • 上一篇    下一篇

白藜芦醇治疗牙周炎及其生物利用度的研究进展

李琼1(),于维先1,2()   

  1. 1.吉林大学口腔医院牙周病科 长春 130021
    2.吉林省牙发育及颌骨重塑与再生重点实验室 长春 130021
  • 收稿日期:2022-05-25 修回日期:2022-09-21 出版日期:2023-01-01 发布日期:2023-01-09
  • 通讯作者: 于维先
  • 作者简介:李琼,硕士,Email:1520972910@qq.com
  • 基金资助:
    吉林省财政厅科技项目(JCSZ2021893-22)

Research progress on resveratrol for the treatment of periodontitis and its bioavailability

Li Qiong1(),Yu Weixian1,2()   

  1. 1.Dept. of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2022-05-25 Revised:2022-09-21 Online:2023-01-01 Published:2023-01-09
  • Contact: Weixian Yu
  • Supported by:
    Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2021-893-22)

摘要:

白藜芦醇是一种在深色葡萄、浆果和花生皮中发现的植物来源的天然多酚化合物,具有广泛的药理学活性。白藜芦醇具有抗炎、抗氧化、抗菌、抑制骨吸收和促进骨形成等生物活性,可用于牙周炎的治疗。白藜芦醇在使用中存在快速吸收、低生物利用度和低水溶性等不足,使用助溶剂和纳米颗粒技术可以改善或解决这些问题。本文就改善白藜芦醇的生物利用度以及治疗牙周炎方面的研究进展进行综述,为进一步利用白藜芦醇作为牙周炎治疗药物并开发更好的药品剂型提供参考。

关键词: 白藜芦醇, 牙周炎, 生物利用度

Abstract:

Resveratrol is a natural polyphenol compound that has extensive pharmacological activities and can be found in plants, such as dark grapes, berries, and peanut skins. Experimental studies showed that it plays a therapeutic role in periodontitis, such as anti-inflammation, anti-oxidation, anti-bacteria, inhibition of bone resorption, and promotion of bone formation. However, resveratrol also faces some problems, such as rapid absorption, low bioavailability, and low water solubility. The improvement of cosolvent and the use of nanoparticles can solve these problems. This article reviews the research progress on resveratrol for the treatment of periodontitis and its bioavailability to provide reference for further research on resveratrol as a therapeutic drug and the development of suitable drug dosage forms.

Key words: resveratrol, periodontitis, bioavailability

中图分类号: 

  • R 781.4

图1

反式(上)和顺式(下)白藜芦醇结构式"

1 Zheng SW, Yu SW, Fan XM, et al. Porphyromonas gingivalis survival skills: immune evasion[J]. J Periodontal Res, 2021, 56(6): 1007-1018.
2 Richards D. Review finds that severe periodontitis affects 11% of the world population[J]. Evid Based Dent, 2014, 15(3): 70-71.
3 Oh WY, Shahidi F. Antioxidant activity of resveratrol ester derivatives in food and biological model systems[J]. Food Chem, 2018, 261: 267-273.
4 Berta GN, Romano F, Vallone R, et al. An innovative strategy for oral biofilm control in early childhood based on a resveratrol-cyclodextrin nanotechnology approach[J]. Materials (Basel), 2021, 14(14): 3801.
5 Jarosova V, Vesely O, Doskocil I, et al. Metabolism of cis- and trans-resveratrol and dihydroresveratrol in an intestinal epithelial model[J]. Nutrients, 2020, 12(3): E595.
6 Trela BC, Waterhouse AL. Resveratrol: isomeric molar absorptivities and stability[J]. J Agric Food Chem, 1996, 44(5): 1253-1257.
7 叶庆元, 李子涵, 王垭铮, 等. 间充质干细胞来源凋亡囊泡缓解牙龈卟啉单胞菌脂多糖诱导下巨噬细胞促炎状态的研究[J]. 中华口腔医学杂志, 2021, 56(8): 791-798.
Ye QY, Li ZH, Wang YZ, et al. Study on the effect of apoptosis vesicle derived from mesenchymal stem cells on the pro-inflammatory state of macrophages induced by lipopolysaccharide of Porphyromonas gingivalis [J]. Chin J Stomatol, 2021, 56(8): 791-798.
8 Ying SQ, Tan MM, Feng G, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress[J]. Theranostics, 2020, 10(21): 9789-9807.
9 Zare Javid A, Hormoznejad R, Yousefimanesh HA, et al. The impact of resveratrol supplementation on blood glucose, insulin, insulin resistance, triglyceride, and periodontal markers in type 2 diabetic patients with chronic periodontitis[J]. Phytother Res, 2017, 31(1): 108-114.
10 Li LH, Li JX, Wang YJ, et al. Resveratrol prevents inflammation and oxidative stress response in LPS-induced human gingival fibroblasts by targeting the PI3K/AKT and Wnt/β‑catenin signaling pathways[J]. Genet Mol Biol, 2021, 44(3): e20200349.
11 Corrêa MG, Pires PR, Ribeiro FV, et al. Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats[J]. PLoS One, 2018, 13(10): e0204414.
12 Cirano FR, Molez AM, Ribeiro FV, et al. Resveratrol and insulin association reduced alveolar bone loss and produced an antioxidant effect in diabetic rats[J]. J Periodontol, 2021, 92(5): 748-759.
13 Javid AZ, Hormoznejad R, Yousefimanesh HA, et al. Impact of resveratrol supplementation on inflammatory, antioxidant, and periodontal markers in type 2 diabetic patients with chronic periodontitis[J]. Diabetes Metab Syndr, 2019, 13(4): 2769-2774.
14 Yuan JK, Wang XX, Ma D, et al. Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway[J]. Mol Med Rep, 2020, 21(5): 2085-2094.
15 Bahar B, Singhrao SK. An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model[J]. Mol Biol Rep, 2021, 48(1): 147-156.
16 Corrêa MG, Absy S, Tenenbaum H, et al. Resveratrol attenuates oxidative stress during experimental periodontitis in rats exposed to cigarette smoke inhalation[J]. J Periodontal Res, 2019, 54(3): 225-232.
17 Kugaji MS, Kumbar VM, Peram MR, et al. Effect of resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease[J]. APMIS, 2019, 127(4): 187-195.
18 Ben Lagha A, Andrian E, Grenier D. Resveratrol attenuates the pathogenic and inflammatory properties of Porphyromonas gingivalis [J]. Mol Oral Microbiol, 2019, 34(3): 118-130.
19 Pothapur KK, Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai Tamil Nadu India. Identification of protein targets in red complex organisms binding with resveratrol[J]. Bioinformation, 2020, 16(11): 837-842.
20 Abdullahi M, Olotu FA, Soliman ME. Solving the riddle: unraveling the mechanisms of blocking the binding of leukotoxin by therapeutic antagonists in periodontal diseases[J]. J Cell Biochem, 2018, 119(11): 9364-9379.
21 Casati MZ, Algayer C, Cardoso da Cruz G, et al. Resveratrol decreases periodontal breakdown and modulates local levels of cytokines during periodontitis in rats[J]. J Periodontol, 2013, 84(10): e58-e64.
22 Wang YJ, Zhao P, Sui BD, et al. Resveratrol enhances the functionality and improves the regeneration of mesenchymal stem cell aggregates[J]. Exp Mol Med, 2018, 50(6): 1-15.
23 Li W, Huang X, Yu W, et al. Activation of functional somatic stem cells promotes endogenous tissue regeneration[J]. J Dent Res, 2022, 101(7): 802-811.
24 Adhikari N, Prasad Aryal Y, Jung JK, et al. Resveratrol enhances bone formation by modulating inflammation in the mouse periodontitis model[J]. J Periodontal Res, 2021, 56(4): 735-745.
25 Lançon A, Delmas D, Osman H, et al. Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process[J]. Biochem Biophys Res Commun, 2004, 316(4): 1132-1137.
26 Gowd V, Karim N, Shishir MRI, et al. Dietary polyphenols to combat the metabolic diseases via altering gut microbiota[J]. Trends Food Sci Technol, 2019, 93: 81-93.
27 Walle T, Hsieh F, DeLegge MH, et al. High absorption but very low bioavailability of oral resveratrol in humans[J]. Drug Metab Dispos, 2004, 32(12): 1377-1382.
28 Wang XC, Parvathaneni V, Shukla SK, et al. Inhalable resveratrol-cyclodextrin complex loaded biodegradable nanoparticles for enhanced efficacy against non-small cell lung cancer[J]. Int J Biol Macromol, 2020, 164: 638-650.
29 Zupančič Š, Lavrič Z, Kristl J. Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature[J]. Eur J Pharm Biopharm, 2015, 93: 196-204.
30 Verheijen M, Lienhard M, Schrooders Y, et al. DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro [J]. Sci Rep, 2019, 9(1): 4641.
31 Loftsson T, Brewster ME. Pharmaceutical applicat-ions of cyclodextrins: basic science and product development[J]. J Pharm Pharmacol, 2010, 62(11): 1607-1621.
32 Davis ME, Brewster ME. Cyclodextrin-based pharmaceutics: past, present and future[J]. Nat Rev Drug Discov, 2004, 3(12): 1023-1035.
33 Savić-Gajić I, Savić I, Nikolić V, et al. The improvement of photostability and antioxidant activity of trans-resveratrol by cyclodextrins[J]. Adv Techol, 2017, 6(2): 18-25.
34 Yang ZQ, Argenziano M, Salamone P, et al. Preclinical pharmacokinetics comparison between resveratrol 2-hydroxypropyl‑β‑cyclodextrin complex and re-sveratrol suspension after oral administration[J]. J Inclusion Phenom Macrocycl Chem, 2016, 86(3/4): 263-271.
35 Lim YRI, Preshaw PM, Lim LP, et al. Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects[J]. Sci Rep, 2020, 10(1): 9072.
36 Javanbakht S, Shaabani A. Carboxymethyl cellulose-based oral delivery systems[J]. Int J Biol Macromol, 2019, 133: 21-29.
37 Li X, Liu XC, Ding X, et al. Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats[J]. Oral Dis, 2022. doi: 10.1111/odi.14148 .
doi: 10.1111/odi.14148
38 Li J, Song S, Meng JS, et al. 2D MOF periodontitis photodynamic ion therapy[J]. J Am Chem Soc, 2021, 143(37): 15427-15439.
39 Chimento A, de Amicis F, Sirianni R, et al. Progress to improve oral bioavailability and beneficial effects of resveratrol[J]. Int J Mol Sci, 2019, 20(6): E1381.
40 Shi JY, Zhang Y, Zhang XM, et al. Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy[J]. J Nanobiotechnology, 2021, 19(1): 429.
41 Kianfar E. Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles[J]. J Nanobiotechnology, 2021, 19(1): 159.
42 Koh LD, Cheng Y, Teng CP, et al. Structures, mechanical properties and applications of silk fibroin materials[J]. Prog Polym Sci, 2015, 46: 86-110.
43 Lozano-Pérez AA, Rivero HC, Pérez Hernández MDC, et al. Silk fibroin nanoparticles: efficient vehicles for the natural antioxidant quercetin[J]. Int J Pharm, 2017, 518(1/2): 11-19.
44 Giménez-Siurana A, Gómez García F, Pagan Bernabeu A, et al. Chemoprevention of experimental periodontitis in diabetic rats with silk fibroin nanoparticles loaded with resveratrol[J]. Antioxidants (Basel), 2020, 9(1): E85.
45 Guo LX, Zhao HY, Zheng X. The clinical effects of resveratrol on atherosclerosis treatment and its effect on the expression of NADPH oxidase complex genes in vascular smooth muscle cell line[J]. Cell Mol Biol (Noisy-le-grand), 2021, 67(3): 148-152.
46 Abozaid OAR, Sallam MW, El-Sonbaty S, et al. Resveratrol-selenium nanoparticles alleviate neuroinflammation and neurotoxicity in a rat model of Alzheimer’s disease by regulating Sirt1/miRNA-134/GSK3β expression[J]. Biol Trace Elem Res, 2022, 200(12): 5104-5114.
[1] 傅豫, 何薇, 黄兰. 铁死亡在口腔疾病中的研究进展[J]. 国际口腔医学杂志, 2024, 51(1): 36-44.
[2] 罗晓洁,王德续,陈晓涛. 基于生物信息学分析铁死亡调控基因与牙周炎的关系[J]. 国际口腔医学杂志, 2023, 50(6): 661-668.
[3] 黄元鸿,彭显,周学东. 骨碎补在治疗口腔骨相关疾病的研究进展[J]. 国际口腔医学杂志, 2023, 50(6): 679-685.
[4] 龚美灵,程兴群,吴红崑. 牙周炎与帕金森病相关性的研究进展[J]. 国际口腔医学杂志, 2023, 50(5): 587-593.
[5] 孙佳,韩烨,侯建霞. 白细胞介素-6-铁调素信号轴调控牙周炎相关性贫血致病机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(3): 329-334.
[6] 刘体倩,梁星,刘蔚晴,李晓虹,朱睿. 咬合创伤在牙周炎发生发展中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2023, 50(1): 19-24.
[7] 黄伟琨,徐秋艳,周婷. 黄芩苷抑制脂多糖促巨噬细胞氧化应激损伤作用的研究[J]. 国际口腔医学杂志, 2022, 49(5): 521-528.
[8] 周剑鹏,谢旭东,赵蕾,王骏. 辅助性T细胞17及白细胞介素17在牙周炎中的作用及机制的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 586-592.
[9] 陈荟宇,白明茹,叶玲. 信号素3A与口腔常见病关系的研究进展[J]. 国际口腔医学杂志, 2022, 49(5): 593-599.
[10] 周佳佳,赵蕾,徐欣. 牙周炎相关基因多态性的研究进展[J]. 国际口腔医学杂志, 2022, 49(4): 432-440.
[11] 马玉,左玉,张鑫. 光动力疗法辅助治疗牙周炎治疗效果的Meta分析[J]. 国际口腔医学杂志, 2022, 49(3): 305-316.
[12] 钱素婷,丁玲敏,纪雅宁,林军. 微小RNA在牙周炎龈沟液中的表达差异及对牙周炎的调控机制[J]. 国际口腔医学杂志, 2022, 49(3): 349-355.
[13] 蒋端,申道南,赵蕾,吴亚菲. 内皮发育调节基因-1与牙周炎相关性的研究进展[J]. 国际口腔医学杂志, 2022, 49(2): 244-248.
[14] 白慧敏,张雨薇,孟姝,刘程程. 特异性促炎症消退介质在牙周炎中作用的研究进展[J]. 国际口腔医学杂志, 2022, 49(1): 85-93.
[15] 黄晓慧,祁本婷,杨洁,刘玉,孙卫斌. 机械性邻面菌斑控制措施对牙周非手术治疗效果影响的系统评价[J]. 国际口腔医学杂志, 2021, 48(6): 656-663.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张新春. 桩冠修复与无髓牙的保护[J]. 国际口腔医学杂志, 1999, 26(06): .
[2] 王昆润. 长期单侧鼻呼吸对头颅发育有不利影响[J]. 国际口腔医学杂志, 1999, 26(05): .
[3] 彭国光. 颈淋巴清扫术中颈交感神经干的解剖变异[J]. 国际口腔医学杂志, 1999, 26(05): .
[4] 杨凯. 淋巴化疗的药物运载系统及其应用现状[J]. 国际口腔医学杂志, 1999, 26(05): .
[5] 康非吾. 种植义齿下部结构生物力学研究进展[J]. 国际口腔医学杂志, 1999, 26(05): .
[6] 柴枫. 可摘局部义齿用Co-Cr合金的激光焊接[J]. 国际口腔医学杂志, 1999, 26(04): .
[7] 孟姝,吴亚菲,杨禾. 伴放线放线杆菌产生的细胞致死膨胀毒素及其与牙周病的关系[J]. 国际口腔医学杂志, 2005, 32(06): 458 -460 .
[8] 费晓露,丁一,徐屹. 牙周可疑致病菌对口腔黏膜上皮的粘附和侵入[J]. 国际口腔医学杂志, 2005, 32(06): 452 -454 .
[9] 赵兴福,黄晓晶. 变形链球菌蛋白组学研究进展[J]. 国际口腔医学杂志, 2008, 35(S1): .
[10] 庞莉苹,姚江武. 抛光和上釉对陶瓷表面粗糙度、挠曲强度及磨损性能的影响[J]. 国际口腔医学杂志, 2008, 35(S1): .