国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (5): 587-593.doi: 10.7518/gjkq.2023087

• 综述 • 上一篇    下一篇

牙周炎与帕金森病相关性的研究进展

龚美灵(),程兴群,吴红崑()   

  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院老年口腔科 成都 610041
  • 收稿日期:2022-12-20 修回日期:2023-05-27 出版日期:2023-09-01 发布日期:2023-09-01
  • 通讯作者: 吴红崑
  • 作者简介:龚美灵，硕士，Email：1139766106@qq.com
  • 基金资助:
    四川省海外留学人员科研项目(2021-29-1);四川大学华西口腔医院人才队伍建设项目(RCDWJS2021-16)

Research progress on the correlation between Parkinson’s disease and periodontitis

Gong Meiling(),Cheng Xingqun,Wu Hongkun.()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-12-20 Revised:2023-05-27 Online:2023-09-01 Published:2023-09-01
  • Contact: Hongkun. Wu
  • Supported by:
    Science and Technology Program for Overseas Students in Sichuan Province(2021-29-1);Research Funding from West China Hospital of Stomatology Sichuan University(RCDWJS2021-16)

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摘要：

帕金森病是一种多见于老年人的神经系统退行性疾病，慢性神经炎症与其病理生理密切相关。牙周炎作为一种常见的口腔慢性炎症性疾病，可引起局部甚至全身炎症，是众多全身疾病的危险因素，但与帕金森病的相关研究还比较缺乏。目前为止，尚无直接证据表明牙周炎在帕金森病的发病机制中起作用，但其可能通过多种途径引起神经炎症，从而影响帕金森病的发生。本文就近年来牙周炎与帕金森病相关的研究进展作一综述，为口腔与全身慢病共同防治提供理论依据。

关键词: 帕金森病, 牙周炎, 神经炎症, 神经退行性疾病, 慢病同治

Abstract:

Parkinson’s disease (PD) is a degenerative disease of nervous system that commonly occurs in the elderly. Chronic neuroinflammation is closely related to its pathophysiology. As one of the most common chronic inflammatory diseases, periodontitis can cause local and even systemic inflammation and is a risk factor for many systemic diseases. The correlation between PD and periodontitis is still unclear. Although no direct evidence confirms that periodontitis plays a role in the pathogenesis of PD, periodontitis may cause neuroinflammation through various ways and thus affect the occurrence of PD. This work reviews the research progress of PD and periodontitis to provide a theoretical basis for the prevention and treatment of oral and systemic chronic diseases.

Key words: Parkinson’s disease, periodontitis, neuroinflammation, neurodegenerative diseases, co-treatment of chronic diseases

中图分类号: 

  • R 781.4
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