国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (5): 587-593.doi: 10.7518/gjkq.2023087

• 综述 • 上一篇    下一篇



  1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院老年口腔科 成都 610041
  • 收稿日期:2022-12-20 修回日期:2023-05-27 出版日期:2023-09-01 发布日期:2023-09-01
  • 通讯作者: 吴红崑
  • 作者简介:龚美灵,硕士,Email:1139766106@qq.com
  • 基金资助:

Research progress on the correlation between Parkinson’s disease and periodontitis

Gong Meiling(),Cheng Xingqun,Wu Hongkun.()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-12-20 Revised:2023-05-27 Online:2023-09-01 Published:2023-09-01
  • Contact: Hongkun. Wu
  • Supported by:
    Science and Technology Program for Overseas Students in Sichuan Province(2021-29-1);Research Funding from West China Hospital of Stomatology Sichuan University(RCDWJS2021-16)



关键词: 帕金森病, 牙周炎, 神经炎症, 神经退行性疾病, 慢病同治


Parkinson’s disease (PD) is a degenerative disease of nervous system that commonly occurs in the elderly. Chronic neuroinflammation is closely related to its pathophysiology. As one of the most common chronic inflammatory diseases, periodontitis can cause local and even systemic inflammation and is a risk factor for many systemic diseases. The correlation between PD and periodontitis is still unclear. Although no direct evidence confirms that periodontitis plays a role in the pathogenesis of PD, periodontitis may cause neuroinflammation through various ways and thus affect the occurrence of PD. This work reviews the research progress of PD and periodontitis to provide a theoretical basis for the prevention and treatment of oral and systemic chronic diseases.

Key words: Parkinson’s disease, periodontitis, neuroinflammation, neurodegenerative diseases, co-treatment of chronic diseases


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