国际口腔医学杂志

国际口腔医学杂志 ›› 2022, Vol. 49 ›› Issue (5): 593-599.doi: 10.7518/gjkq.2022085

• 综述 • 上一篇    下一篇

信号素3A与口腔常见病关系的研究进展

陈荟宇(),白明茹,叶玲()   

  1. 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科 成都 610041
  • 收稿日期:2021-12-06 修回日期:2022-04-06 出版日期:2022-09-01 发布日期:2022-09-16
  • 通讯作者: 叶玲
  • 作者简介:陈荟宇，硕士，Email：417823395@qq.com
  • 基金资助:
    国家自然科学基金青年科学基金(82001020)

Progress in understanding the correlations between semaphorin 3A and common oral diseases

Chen Huiyu(),Bai Mingru,Ye Ling.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-12-06 Revised:2022-04-06 Online:2022-09-01 Published:2022-09-16
  • Contact: Ling. Ye
  • Supported by:
    National Natural Science Foundation of China Youth Science Foundation(82001020)

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摘要：

信号素3A（Sema3A）是一种分泌型蛋白，具有调节血管形成、肿瘤生长、骨代谢以及机体免疫应答等功能。口腔疾病是人体的常见病、多发病，某些口腔常见疾病的发展进程伴随着Sema3A的表达改变。Sema3A能够抑制根尖周炎和牙髓炎进程中促炎因子的表达，阻止炎症进程，还能与血管内皮生长因子竞争结合其受体从而抑制肿瘤血管形成。Sema3A作为重要的信号分子，在口腔疾病中的作用越来越受到学者们的重视。探究Sema3A在牙髓炎、牙周炎、根尖周炎、牙发育异常和口腔癌等常见口腔疾病进程中的作用，对于全面剖析这些疾病的分子机制、研发治疗药物和治疗方法有着深远的意义。本文就Sema3A与口腔常见病的关系及相关分子机制进行综述。

关键词: 信号素3A, 牙髓炎, 根尖周, 牙周炎, 牙发育疾病, 口腔癌

Abstract:

Semaphorin 3A (Sema3A) is a membrane-associated secreted protein produced by endothelial cells that regulate vascularization, cancer progression, bone biology, and immune homeostasis. Oral diseases are common and frequently occur in the human body. In recent years, an increasing number of studies have found that Sema3A expression changes with the progression of some common oral diseases. Sema3A inhibits apical periodontitis and pulpitis by inhibiting the expression of pro-inflammatory mediators to repress inflammation. In addition, it can also compete with vascular endothelial growth factors to bind its receptors to inhibit tumor angiogenesis. Oral diseases are represented by pulpitis, periodontitis, periapical periodontitis, dental dysplasia, and oral cancer. Exploring the role of Sema3A in oral diseases is of far-reaching significance for the comprehensive analysis of the molecular mechanisms in the diseases and the development of therapeutic drugs for intervention and treatment methods. In this paper, we will discuss the correlations between Sema3A and oral diseases and their molecular mechanisms.

Key words: semaphorin 3A, pulpitis, apical periodontitis, periodontitis, dental dysplasia, oral cancer

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