国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (4): 407-413.doi: 10.7518/gjkq.2023068
Jiang Yueying(),He Yutian,Li Ting,Zhou Ronghui.()
摘要:
荧光成像因具有侵入性低、灵敏度高、可实时检测等优点,在癌症诊断及药物靶向等研究领域备受关注。自体荧光检查术可利用病变组织与正常组织对同一波长激发光产生的荧光差异对癌变组织进行诊断,或是利用药物本身的荧光对癌变组织进行示踪。然而,上述荧光诊断技术的特异性较差且检测灵敏度相对较低。与现有荧光诊断方法相比,近红外荧光诊断技术受背景信号干扰小且能对更深部组织进行成像,可有效弥补自体荧光检查术的不足,对辅助临床上口腔癌症的诊断具有重要意义。基于此,本文综述了应用于口腔癌诊断领域的第一、二近红外荧光窗口成像探针的构建方法,并进一步讨论了其在标记口腔癌症中的研究进展,为实现口腔癌实时精准诊断研究提供参考。
中图分类号:
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