国际口腔医学杂志

国际口腔医学杂志 ›› 2023, Vol. 50 ›› Issue (1): 120-126.doi: 10.7518/gjkq.2023015

• 综述 • 上一篇    

巨噬细胞源性外泌体调控骨改建的研究进展

刘艺(),刘奕()   

  1. 中国医科大学附属口腔医院正畸科 沈阳 110013
  • 收稿日期:2022-06-06 修回日期:2022-10-17 出版日期:2023-01-01 发布日期:2023-01-09
  • 通讯作者: 刘艺,刘奕
  • 作者简介:刘艺，硕士，Email：yliu@cmu.edu.cn
  • 基金资助:
    辽宁省重点研发计划项目(2020JH2/10300038)

Research progress on the regulation of bone remodeling by macrophage-derived exosomes

Liu Yi(),Liu Yi.()   

  1. Dept. of Orthodontics, The Affiliated Hospital of Stomatology, China Medical University, Shenyang 110013, China
  • Received:2022-06-06 Revised:2022-10-17 Online:2023-01-01 Published:2023-01-09
  • Contact: Yi Liu,Yi. Liu
  • Supported by:
    Liaoning Province Key Research and Development Plan Project(2020JH2/10300038)

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摘要：

巨噬细胞是人体固有免疫的主要成分，与骨组织关系密切。外泌体是由所有细胞释放的纳米级囊泡，携带来源细胞的核酸等信息调节靶细胞功能。研究表明巨噬细胞释放的外泌体能够有效调节骨骼改建，通过多种方式影响微环境，进而影响成骨。本文总结巨噬细胞源性外泌体作用于骨改建的研究进展，为开发治疗策略提供参考。

关键词: 巨噬细胞, 外泌体, 骨改建, 炎症

Abstract:

Macrophages are the major components of human innate immunity and are closely related to bone tissue. Exosomes are nanoscale vesicles released by all cells, thus carrying nucleic acid and other information from the source cells to organize the function of target cells. Studies have demonstrated that macrophage-derived exosomes can effectively regulate bone remodeling, modulate the microenvironment in a variety of ways, and then affect osteogenesis. This paper summarizes the research progress onthe effect of macrophage-derived exosomes on bone remodeling to provide a reference for the development of therapeutic strategies.

Key words: macrophages, exosome, bone remodeling, inflammation

中图分类号: 

  • R 783.5

图1

M1巨噬细胞外泌体对骨改建信号通路的调节"

图 2

M2外泌体对骨改建信号通路的调节"

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