国际口腔医学杂志

国际口腔医学杂志 ›› 2021, Vol. 48 ›› Issue (3): 341-346.doi: 10.7518/gjkq.2021037

• 综述 • 上一篇    下一篇

沉默信息调节因子1调控牙周炎发生发展的机制

周丰1(),陈野1,陈晨2,张奕宁2,耿瑞蔓2,刘戟2()   

  1. 1.口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医学院 成都 610041
    2.四川大学华西基础医学与法医学院 成都 610041
  • 收稿日期:2020-08-16 修回日期:2020-12-24 出版日期:2021-05-01 发布日期:2021-05-14
  • 通讯作者: 刘戟
  • 作者简介:周丰,学士,Email: 280606885@qq.com

Mechanism of sirtuin 1 in regulating periodontitis

Zhou Feng1(),Chen Ye1,Chen Chen2,Zhang Yining2,Geng Ruiman2,Liu Ji2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. West China School of Basic Medical Science and Forensic Medicine, Sichuan University, Chengdu 610041, China
  • Received:2020-08-16 Revised:2020-12-24 Online:2021-05-01 Published:2021-05-14
  • Contact: Ji Liu

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摘要：

牙周炎是发生在牙周组织的炎症性破坏性疾病。牙周炎由牙菌斑作为始动因子,介导氧化应激和继发性炎症反应,导致组织破坏、牙槽骨吸收,最终牙齿松动、脱落。沉默信息调节因子1（SIRT1）作为重要的长寿因子,在抗老化、抵抗应激、介导凋亡与自噬和调控炎症反应过程中扮演重要的角色。近年来一些研究从氧化应激、炎症因子通路及全身疾病等多角度入手,探究SIRT1与牙周炎发生发展之间的关系。本文就SIRT1与牙周炎之间的关系、具体机制、临床应用前景作一综述,为牙周炎的治疗提供参考与借鉴。

关键词: 沉默信息调节因子1, 牙周炎, 氧化应激, 炎症, 自噬

Abstract:

Periodontitis is a species of inflammatory, destructive diseases that occur in periodontal tissues. As the starting factor of periodontitis, dental plaque mediates oxidative stress and secondary inflammation, which leads to tissue destruction, alveolar bone absorption, and tooth loosening and loss. Sirtuin 1 (SIRT1), an important longevity factor, plays a vital role in antiaging and antistress applications, mediating apoptosis, autophagy, and regulating inflammation reaction. In recent years, several studies explored the relationship between SIRT1 and the occurrence and development of periodontitis from multiple perspectives, such as oxidative stress, inflammatory factors and pathways, and systemic diseases. This study reviews the relationship between SIRT1 and periodontitis, the possible mechanism, and its future clinical application to provide reference.

Key words: sirtuin 1, periodontitis, oxidative stress, inflammation, autophagy

中图分类号: 

  • R782
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